2. Epigenetics Neuronal Signaling
  3. Histone Demethylase Amyloid-β
  4. LSD1-IN-43

LSD1-IN-43 is a highly selective, reversible, orally active and brain-penetrant LSD1 inhibitor with an IC50 value of 0.8 μM. LSD1-IN-43 has low inhibitory activity against MAO-A and MAO-B, two homologs of LSD1. LSD1-IN-43 significantly inhibits Aβ aggregation and enhances Aβ-induced neuronal cell viability. LSD1-IN-43 can be used for the study of Alzheimer’s disease (AD)[1].

For research use only. We do not sell to patients.

LSD1-IN-43 Chemical Structure

LSD1-IN-43 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

LSD1-IN-43 Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LSD1-IN-43 is a highly selective, reversible, orally active and brain-penetrant LSD1 inhibitor with an IC50 value of 0.8 μM. LSD1-IN-43 has low inhibitory activity against MAO-A and MAO-B, two homologs of LSD1. LSD1-IN-43 significantly inhibits Aβ aggregation and enhances Aβ-induced neuronal cell viability. LSD1-IN-43 can be used for the study of Alzheimer’s disease (AD)[1].

In Vitro

LSD1-IN-43 (10 μM) exhibits a highly selective and reversible inhibitory effect on LSD1, with minimal activity against MAO-A (7% inhibition) and MAO-B (4.9% inhibition)[1].

LSD1-IN-43 (25-100 μM) exhibits the low toxicity and effectively reduces Aβ1-42 generation levels in HT22 cells[1].

LSD1-IN-43 (10 μM) exhibits a significant inhibitory effect on Aβ1-42 aggregation, with a rate of 66.19%, which is much higher than 49.98% for Curcumin (HY-N0005)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-43 Related Antibodies
In Vivo

LSD1-IN-43 (125-500 μM, 24-56 h) demonstrates a concentration-dependent ability to extend the lifespan and reduces paralysis onset in the CL4176 transgenic C. elegans model[1].


LSD1-IN-43 (40-80mg/kg, i.g.) restores the expression of H3K9me2 expression-a histone marker regulated by LSD1, while simultaneously improving learning, memory, and cognitive function deficits in this AD mouse mode [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP/PS1 Mice (5 weeks)[1]
Dosage: 40, 80 mg/kg
Administration: Intragastric administration (i.g.)
Result: Improved performance in the Morris Water Maze compared to the saline-treated APP/PS1 group.
Reduced escape latency and improved ability to locate the hidden platform compared to the saline-treated APP/PS1 group.
Increased correct alternations and better spatial recognition compared to the saline-treated APP/PS1 group.
Reduced the expression of neuroinflammatory markers (IBAI for microglia and GFAP for astrocytes) and inflammatory cytokines (IL-1β and TNF-α) in the hippocampal CA1 region of APP/PS1 mice compared to the saline-treated group.
Reduced Aβ 1-42 deposition in the hippocampus ,with high-dose treatment (80 mg/kg) showing a more pronounced reduction compared to the saline-treated APP/PS1 group.
Restored the expression of H3K9me2,which is a histone marker regulated by LSD1 compared to the saline-treated APP/PS1 group.
Increased inneuron density and compact arrangement, reduced inuclear pyknosis and cytoplasmic vacuolation compared to the saline-treated APP/PS1 group.
Molecular Weight

377.43

Formula

C23H23NO4
SMILES

C[C@@]12[C@](CC(C3=C2)=C(C)C(O3)=O)([H])C(CC4=CNC5=C4C(O)=CC=C5)C(CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LSD1-IN-43 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-43Histone DemethylaseAmyloid-ββ-amyloid peptideAβAbetaAlzheimer’s diseaseLSD1 inhibitorAtractylodes macrocephalaamyloid βneuroinflammationcognitionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LSD1-IN-43
Cat. No.:
HY-176254
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.