2. Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Pyroptosis Reactive Oxygen Species (ROS) Interleukin Related Caspase
  4. Troponin-IN-1

Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury.

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Troponin-IN-1

Troponin-IN-1 Chemical Structure

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Troponin-IN-1 Related Antibodies

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Description

Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury[1].

In Vitro

Troponin-IN-1 (Compound 19) (0.1-10 μM, 24 h) enhances viability of OGD/R-injured H9c2 cardiomyocytes , reduces LDH leakage and inhibits ROS accumulation[1].
Troponin-IN-1 (10-50 μM) decreases pyroptotic H9c2 cells, maintains cell morphology and blocks pyroptosis by inhibiting caspase-1/GSDMD/IL-18 pathway[1].
Troponin-IN-1 (6.25-100 μM, pretreatment for 30 min) inhibits NO production in LPS (HY-D1056)-induced RAW264.7 cells (IC50 = 13.49 μM) and reduces IL-1β, TNF-α, IL-18 release[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Troponin-IN-1 Related Antibodies

ELISA Assay[1]

Cell Line: LPS (HY-D1056)-induced RAW264.7 cells
Concentration: 10, 30, 50 μM
Incubation Time: Pretreatment for 30 min
Result: Reduced IL-1β, TNF-α, IL-18 release.
In Vivo

Troponin-IN-1 (Compound 19) (20-80 mg/kg, intraperitoneal injection, once daily for 7 days, last dose 1 h before surgery) reduces myocardial infarct size in LAD-induced MI/R male Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats: chest opened between 3rd and 4th ribs, left anterior descending coronary artery (LAD) ligated for 45 min, then ligature loosened for 24 h reperfusion to establish myocardial ischemia/reperfusion (MI/R) model[1]
Dosage: 20, 40, 80 mg/kg
Administration: intraperitoneal injection, once daily for 7 days, last dose 1 h before surgery
Result: Reduced myocardial infarct size.
Decreased serum cTn1 level, increased serum SOD activity.
Decreased serum MDA content.
Alleviated myocardial cell necrosis and inflammatory infiltration.
Showed no significant changes in body weight.
Molecular Weight

374.47

Formula

C22H30O5
SMILES

O=C(O[C@@H]1[C@](C2(C)C)(C)CC[C@@H]2C1)/C=C/C3=CC=C(OC)C(OC)=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Troponin-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Troponin-IN-1PyroptosisReactive Oxygen Species (ROS)Interleukin RelatedCaspaseILBorneol derivativesCardioprotectiveMyocardial ischemia reperfusionInhibitorinhibitorinhibit

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