2. Apoptosis
  3. TNF Receptor
  4. TWEAK-Fn14-IN-1

TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent TWEAK-Fn14 inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a KD of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects.

For research use only. We do not sell to patients.

TWEAK-Fn14-IN-1 Chemical Structure

TWEAK-Fn14-IN-1 Chemical Structure

CAS No. : 951612-19-4

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TWEAK-Fn14-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent TWEAK-Fn14 inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a KD of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects[1].

IC50 & Target

TWEAK

 

Molecular Weight

308.79

Formula

C13H13ClN4OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCSCC1)C2=CN(N=N2)C3=CC=CC(Cl)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (80.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2384 mL 16.1922 mL 32.3845 mL
5 mM 0.6477 mL 3.2384 mL 6.4769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2384 mL 16.1922 mL 32.3845 mL 80.9612 mL
5 mM 0.6477 mL 3.2384 mL 6.4769 mL 16.1922 mL
10 mM 0.3238 mL 1.6192 mL 3.2384 mL 8.0961 mL
15 mM 0.2159 mL 1.0795 mL 2.1590 mL 5.3974 mL
20 mM 0.1619 mL 0.8096 mL 1.6192 mL 4.0481 mL
25 mM 0.1295 mL 0.6477 mL 1.2954 mL 3.2384 mL
30 mM 0.1079 mL 0.5397 mL 1.0795 mL 2.6987 mL
40 mM 0.0810 mL 0.4048 mL 0.8096 mL 2.0240 mL
50 mM 0.0648 mL 0.3238 mL 0.6477 mL 1.6192 mL
60 mM 0.0540 mL 0.2699 mL 0.5397 mL 1.3494 mL
80 mM 0.0405 mL 0.2024 mL 0.4048 mL 1.0120 mL
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TWEAK-Fn14-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TWEAK-Fn14-IN-1951612-19-4TNF ReceptorTumor Necrosis Factor ReceptorTNFRmigrationTWEAKglioma cellInhibitorinhibitorinhibit

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