EGFR-IN-177 

EGFR-IN-177 is a potent EGFR inhibitor with IC₅₀s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer^[1].

EGFR-IN-177 (Example 54) inhibits EGFR phosphorylation in PC-9, H1975 and A431 cells with IC₅₀s of 0.67, 0.94 and 10.66 nM^[1].
EGFR-IN-177 (5 days) inhibits in PC-9, H1975 and A431 cells proliferation with IC₅₀s of 0.78, 0.99 and 0.41 nM^[1].
EGFR-IN-177 (3 days) inhibits proliferation of BaF3 cells with engineered EGFR L858R/T790M/C797S, EGFR L858R/C797S and EGFR d746-750/T790M transgene with IC₅₀s of 0.55, 0.06 and 0.55 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

520.63

C₂₇H₃₆N₈O₃

3062177-59-4

OC[C@@H](N1C2=C(/C=C/C(C3=CC(C4=C(N(N=C4C)C)O[C@H](CN(C2)C)C)=N5)=NNC3=C5C)C(OCC)=N1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jingrong Jean Cui, et al. EGFR inhibitors for treating disease. WO2024229091.