1. Epigenetics
  2. Histone Methyltransferase
  3. PRMT5-MTA-IN-5

PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers.

For research use only. We do not sell to patients.

PRMT5-MTA-IN-5 Chemical Structure

PRMT5-MTA-IN-5 Chemical Structure

CAS No. : 3078322-88-7

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Description

PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers[1].

IC50 & Target

PRMT5

1.15 nM (IC50)

Molecular Weight

481.52

Formula

C27H24FN7O

CAS No.
SMILES

NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(N5CC(C5)=C)=CC(C)=C4F)N(C)N=C3)C=C21)=O

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PRMT5-MTA-IN-5
Cat. No.:
HY-176702
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