HPK1-IN-58

Cat. No.: HY-172875: Data Sheet Handling Instructions
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HPK1-IN-58 is an inhibitor of HPK1 (IC₅₀: 2.6 nM) and SLP76 (IC₅₀: 20 nM). HPK1-IN-58 enhances IL-2 secretion and reverses PGE2-induced immunosuppression. HPK1-IN-58 can be used in anti-tumor immunity research.

For research use only. We do not sell to patients.

HPK1-IN-58 Chemical Structure

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This product is a controlled substance and not for sale in your territory.

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Parmacokinetics^[1]

Species	Dose	Route	Indicator	value
Mice	1 mg/kg	i.v.	AUC_0-t	0.424 μg·h/mL
Mice	10 mg/kg	i.g.	AUC_0-t	0.136 μg·h/mL
Mice	1 mg/kg	i.v.	AUC_0-∞	0.431 μg·h/mL
Mice	10 mg/kg	i.g.	AUC_0-∞	0.138 μg·h/mL
Mice	1 mg/kg	i.v.	MRT_0-t	1.90 hr
Mice	10 mg/kg	i.g.	MRT_0-t	5.76 hr
Mice	1 mg/kg	i.v.	T_1/2	1.50 hr
Mice	10 mg/kg	i.g.	T_1/2	3.84 hr
Mice	1 mg/kg	i.v.	F	32.08 %
Mice	10 mg/kg	i.g.	T_max	1 hr
Mice	10 mg/kg	i.g.	C_max	159 ng/mL

Molecular Weight

470.57

Formula

C₂₆H₃₀N₈O

SMILES

CNCC1=NC(N2C(C)(C)CCC2)=CC3=C1CN(C4=NC(C5=NN=C6N5C(C7)C7C6)=CC=C4)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yin Y, et al. Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 May 1;161:108554. [Content Brief]

HPK1-IN-58 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-58MAP4KInterleukin RelatedMAPK Kinase Kinase KinaseILanti-tumor immunityJurkat cellsIL-2Inhibitorinhibitorinhibit

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