2. Academic Validation
  3. Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors

Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors

  • Bioorg Chem. 2025 Jul 1:161:108554. doi: 10.1016/j.bioorg.2025.108554.
Yuan Yin 1,  Chengqi Wang 1,  Huan Liang 1,  Yanpeng Ji 1,  Damin Zhao 1,  Lilong Wang 1,  Wei Shi 1,  Xiaojin Wang 1,  Yong Gao 2,  Baomin Liu 3
Affiliations

Affiliations

  • 1 Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China.
  • 2 Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China. Electronic address: yong.gao1@cttq.com.
  • 3 Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China. Electronic address: baomin.liu@cttq.com.
PMID: 40347769 DOI: 10.1016/j.bioorg.2025.108554
Keywords

2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives; Cancer immunotherapy; HPK1 inhibitors; Immunotherapy.

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