2. Apoptosis
  3. Bcl-2 Family
  4. MCL-1/BCL-2-IN-4

MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor.

For research use only. We do not sell to patients.

MCL-1/BCL-2-IN-4

MCL-1/BCL-2-IN-4 Chemical Structure

CAS No. : 2163793-56-2

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Based on 1 publication(s) in Google Scholar

MCL-1/BCL-2-IN-4 Related Antibodies

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Description

MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor[1].

Molecular Weight

555.44

Formula

C26H23BrN2O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCCCC(NCCN(C(C1=CC=C(SC2=CC=C(Br)C=C2)C3=CC=CC4=C13)=O)C4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (180.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8004 mL 9.0019 mL 18.0037 mL
5 mM 0.3601 mL 1.8004 mL 3.6007 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8004 mL 9.0019 mL 18.0037 mL 45.0094 mL
5 mM 0.3601 mL 1.8004 mL 3.6007 mL 9.0019 mL
10 mM 0.1800 mL 0.9002 mL 1.8004 mL 4.5009 mL
15 mM 0.1200 mL 0.6001 mL 1.2002 mL 3.0006 mL
20 mM 0.0900 mL 0.4501 mL 0.9002 mL 2.2505 mL
25 mM 0.0720 mL 0.3601 mL 0.7201 mL 1.8004 mL
30 mM 0.0600 mL 0.3001 mL 0.6001 mL 1.5003 mL
40 mM 0.0450 mL 0.2250 mL 0.4501 mL 1.1252 mL
50 mM 0.0360 mL 0.1800 mL 0.3601 mL 0.9002 mL
60 mM 0.0300 mL 0.1500 mL 0.3001 mL 0.7502 mL
80 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5626 mL
100 mM 0.0180 mL 0.0900 mL 0.1800 mL 0.4501 mL
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MCL-1/BCL-2-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCL-1/BCL-2-IN-42163793-56-2Bcl-2 FamilyInhibitorinhibitorinhibit

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