POLRMT-IN-2 

POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC₅₀ of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia(AML)^[1].

POLRMT-IN-2 (Compound 10a) (0-100 μM, 48 h) inhibits POLRMT activity dose-dependently in MOLM-13 cells, with an EC₅₀ value of 2.208 μΜ for ND1 expression suppression^[1].

POLRMT-IN-2 (48 h) shows anti-proliferation activity in cells with IC₅₀s of 1.01 μΜ (MOLM-13 cells), 3.24 μΜ (MV4-11 cells) and 14.17 μΜ (HL-60 cells)^[1].

POLRMT-IN-2 (5 μM, 48 h) can inhibit the proliferation of MOLM-13 cells, as evidenced by the reduction in EdU-positive cells and decreased Ki67 expression^[1].

POLRMT-IN-2 (0-10 μM, 48 h) disrupts mitochondrial function in MOLM-13 cells, as demonstrated by dose-dependent increases in ROS levels, decreases in ATP content, and reduction of mitochondrial membrane potential^[1].

POLRMT-IN-2 (0-10 μM, 48 h) induces apoptosis and reduces the expression of both AKT and p-AKTSer473 in MOLM-13 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

576.64

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• [1]. Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J. Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia. Chem Biol Drug Des. 2025 May;105(5):e70127.  [Content Brief]