2. Metabolic Enzyme/Protease Neuronal Signaling Autophagy
  3. Endogenous Metabolite Amyloid-β Autophagy
  4. Phytic acid (50% in water)

Phytic acid (50% in water)  (Synonyms: Inositol hexaphosphate; SNF472 free acid)

Cat. No.: HY-N0814 Purity: 99.31%
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Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.

For research use only. We do not sell to patients.

Phytic acid (50% in water)

Phytic acid (50% in water) Chemical Structure

CAS No. : 83-86-3

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500 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phytic acid (50% in water):

Phytic acid (50% in water) Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Phytic acid (50% in water)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research[1][2][3][4][5][6][7][8][9][10].

IC50 & Target

Xanthine oxidase[3]
In Vitro

Phytic acid (0.05%-0.4% (wt/wt), 5 min) and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains[2].
Phytic acid (1-5 mM, 2-3 h) decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells[3].
Phytic acid (48-72 h) provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells[5].
Phytic acid (≥1 mM) stimulates suicidal human erythrocyte death[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phytic acid (50% in water) Related Antibodies

Cell Viability Assay[3]

Cell Line: Caco-2
Concentration: 1, 2, 2.5, 3.5, 5 mM
Incubation Time: 3 h
Result: Showed over 90% of the cells were viable when IP6 concentrations of 1-5 mM were used during the experiments.
In Vivo

Phytic acid (2%, diet, ad libitum for 21 d) reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na[4].
Phytic acid (2%, drinking water, 6 months) improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) suppresses ischemia-induced hydroxyl radical generation in rat myocardium[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) shows protective effects against CCl4-induced liver fibrosis in mice[8].
Phytic acid (4% of rodent chow, diet, 30 days) reduces lipogenic enzyme activities in diabetic rats[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively[10].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Piglets with an initial BW of 7.40 kg[4]
Dosage: 2% (Phytic acid/food)
Administration: diet, 21 days
Result: Did not affect the blood plasma glucose and Na concentrations.
Reduced total potential difference and total short-circuit current.
Did not affect the blood plasma glucose and Na concentrations.
Did not affect the SGLT1 protein expression.
Clinical Trial
Molecular Weight

660.04

Formula

C6H18O24P6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (151.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 30 mg/mL (45.45 mM)

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.5151 mL 7.5753 mL 15.1506 mL 37.8765 mL
5 mM 0.3030 mL 1.5151 mL 3.0301 mL 7.5753 mL
10 mM 0.1515 mL 0.7575 mL 1.5151 mL 3.7876 mL
15 mM 0.1010 mL 0.5050 mL 1.0100 mL 2.5251 mL
20 mM 0.0758 mL 0.3788 mL 0.7575 mL 1.8938 mL
25 mM 0.0606 mL 0.3030 mL 0.6060 mL 1.5151 mL
30 mM 0.0505 mL 0.2525 mL 0.5050 mL 1.2625 mL
40 mM 0.0379 mL 0.1894 mL 0.3788 mL 0.9469 mL
DMSO 50 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7575 mL
60 mM 0.0253 mL 0.1263 mL 0.2525 mL 0.6313 mL
80 mM 0.0189 mL 0.0947 mL 0.1894 mL 0.4735 mL
100 mM 0.0152 mL 0.0758 mL 0.1515 mL 0.3788 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Phytic acid (50% in water) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phytic acid (50% in water)83-86-3Inositol hexaphosphateSNF472SNF 472SNF-472Endogenous MetaboliteAmyloid-βAutophagyβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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