2. Metabolic Enzyme/Protease Neuronal Signaling Autophagy
  3. Endogenous Metabolite Amyloid-β Autophagy
  4. Zinc Phytate

Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.

For research use only. We do not sell to patients.

Zinc Phytate

Zinc Phytate Chemical Structure

CAS No. : 63903-51-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Zinc Phytate:

Zinc Phytate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Zinc Phytate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research[1][2][3][4][5][6][7][8][9][10].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Zinc Phytate (Phytic acid; 0.05%-0.4% (wt/wt), 5 min) and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains[2].
Zinc Phytate (Phytic acid; 1-5 mM, 2-3 h) decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells[3].
Zinc Phytate (Phytic acid; 48-72 h) provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells[5].
Zinc Phytate (Phytic acid; ≥1 mM) stimulates suicidal human erythrocyte death[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zinc Phytate Related Antibodies

Cell Viability Assay[3]

Cell Line: Caco-2
Concentration: 1, 2, 2.5, 3.5, 5 mM
Incubation Time: 3 h
Result: Showed over 90% of the cells were viable when IP6 concentrations of 1-5 mM were used during the experiments.
In Vivo

Zinc Phytate (Phytic acid; 2%, diet, ad libitum for 21 d) reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na[4].
Zinc Phytate (Phytic acid; 2%, drinking water, 6 months) improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice[5].
Zinc Phytate (Phytic acid; 20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) suppresses ischemia-induced hydroxyl radical generation in rat myocardium[7].
Zinc Phytate (Phytic acid; 100 mg/kg/d, gavage, five days a week, 8 weeks) shows protective effects against CCl4-induced liver fibrosis in mice[8].
Phytic acid (Phytic acid; 4% of rodent chow, diet, 30 days) reduces lipogenic enzyme activities in diabetic rats[9].
Zinc Phytate (Phytic acid; 1-2 g/100 g, in water, 13 weeks) shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively[10].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Piglets with an initial BW of 7.40 kg[4]
Dosage: 2% (Phytic acid/food)
Administration: diet, 21 days
Result: Did not affect the blood plasma glucose and Na concentrations.
Reduced total potential difference and total short-circuit current.
Did not affect the blood plasma glucose and Na concentrations.
Did not affect the SGLT1 protein expression.
Molecular Weight

1040.22

Formula

C6H6O24P6Zn6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P([O-])([O-])O[C@H]([C@H]([C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O)OP([O-])([O-])=O)[C@H]([C@H]1OP([O-])([O-])=O)OP([O-])([O-])=O.[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (48.07 mM; Need ultrasonic)

10%TFA : 50 mg/mL (48.07 mM; ultrasonic and adjust pH to 2 with 10%TFA)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9613 mL 4.8067 mL 9.6134 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.20%

SDS (393 KB)

COA (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 10%TFA 1 mM 0.9613 mL 4.8067 mL 9.6134 mL 24.0334 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL 4.8067 mL
10 mM 0.0961 mL 0.4807 mL 0.9613 mL 2.4033 mL
15 mM 0.0641 mL 0.3204 mL 0.6409 mL 1.6022 mL
20 mM 0.0481 mL 0.2403 mL 0.4807 mL 1.2017 mL
25 mM 0.0385 mL 0.1923 mL 0.3845 mL 0.9613 mL
30 mM 0.0320 mL 0.1602 mL 0.3204 mL 0.8011 mL
40 mM 0.0240 mL 0.1202 mL 0.2403 mL 0.6008 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Zinc Phytate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinc Phytate63903-51-5Endogenous MetaboliteAmyloid-βAutophagyβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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