2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. CatD-IN-1

CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM. CatD-IN-1 holds potential for research in the field of osteoarthritis .

For research use only. We do not sell to patients.

CatD-IN-1

CatD-IN-1 Chemical Structure

CAS No. : 1628521-28-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

CatD-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM. CatD-IN-1 holds potential for research in the field of osteoarthritis [1].

Molecular Weight

441.27

Formula

C18H18Cl2N4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1=CC(OC)=C(C=C1[N+]([O-])=O)OC)NC(NCC2=CC=C(C(Cl)=C2)Cl)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2662 mL 11.3309 mL 22.6619 mL
5 mM 0.4532 mL 2.2662 mL 4.5324 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2662 mL 11.3309 mL 22.6619 mL 56.6547 mL
5 mM 0.4532 mL 2.2662 mL 4.5324 mL 11.3309 mL
10 mM 0.2266 mL 1.1331 mL 2.2662 mL 5.6655 mL
15 mM 0.1511 mL 0.7554 mL 1.5108 mL 3.7770 mL
20 mM 0.1133 mL 0.5665 mL 1.1331 mL 2.8327 mL
25 mM 0.0906 mL 0.4532 mL 0.9065 mL 2.2662 mL
30 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8885 mL
40 mM 0.0567 mL 0.2833 mL 0.5665 mL 1.4164 mL
50 mM 0.0453 mL 0.2266 mL 0.4532 mL 1.1331 mL
60 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL
80 mM 0.0283 mL 0.1416 mL 0.2833 mL 0.7082 mL
100 mM 0.0227 mL 0.1133 mL 0.2266 mL 0.5665 mL
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CatD-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CatD-IN-11628521-28-7CathepsinInhibitorinhibitorinhibit

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HY-148298
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