2. Immunology/Inflammation
  3. IFNAR
  4. VISTA-IN-3

VISTA-IN-3 (Compound A4) is a potent VISTA small molecule inhibitor with a KD value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody.

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VISTA-IN-3 Chemical Structure

VISTA-IN-3 Chemical Structure

CAS No. : 2994662-45-0

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Based on 1 publication(s) in Google Scholar

VISTA-IN-3 Related Antibodies

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Description

VISTA-IN-3 (Compound A4) is a potent VISTA small molecule inhibitor with a KD value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody[1].

Molecular Weight

290.32

Formula

C14H18N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC(NC2=NC(OC)=CC(CNCCO)=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.25 mg/mL (21.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4445 mL 17.2224 mL 34.4447 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4445 mL 17.2224 mL 34.4447 mL 86.1119 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL 17.2224 mL
10 mM 0.3444 mL 1.7222 mL 3.4445 mL 8.6112 mL
15 mM 0.2296 mL 1.1482 mL 2.2963 mL 5.7408 mL
20 mM 0.1722 mL 0.8611 mL 1.7222 mL 4.3056 mL
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VISTA-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VISTA-IN-32994662-45-0IFNARInterferon-α/β receptorInterferon-alpha/beta receptorVISTAInhibitorPBMCsAnti-cancerinhibitorinhibit

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