2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis Caspase RAD51 DNA/RNA Synthesis
  4. HDAC6-IN-63

HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145  nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research.

For research use only. We do not sell to patients.

HDAC6-IN-63

HDAC6-IN-63 Chemical Structure

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HDAC6-IN-63 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145  nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research[1].

IC50 & Target[1]

HDAC6

145 nM (IC50)

Caspase-9

 

Caspase-3

 

Caspase-7

 

HDAC1

4106 nM (IC50)

HDAC4

1738 nM (IC50)

Molecular Weight

445.53

Formula

C25H23N3O3S
SMILES

O=C(N(C(C1=CC=CC=C12)=O)CCC3=CC=CC=C3)N2CC(C=C4)=CC=C4NC(CS)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-63HDACApoptosisCaspaseRAD51DNA/RNA SynthesisHistone deacetylasesHDAC6Sp1A549 and MRC-5 cellsAntitumorEtoposideGemcitabineDNA DSB repairNSCLCChemotherapyInhibitorinhibitorinhibit

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