2. Anti-infection
  3. Fungal
  4. CYP51-IN-22

CYP51-IN-22 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-22 is the non-deuterated form of CYP51-IN-23-d3 (HY-174353S). CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).

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CYP51-IN-22 Chemical Structure

CYP51-IN-22 Chemical Structure

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CYP51-IN-22 Related Antibodies

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Description

CYP51-IN-22 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-22 is the non-deuterated form of CYP51-IN-23-d3 (HY-174353S). CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs)[1].

In Vitro

CYP51-IN-22 (Compound V23) (1-16 ml, 48 h) shows broad-spectrum activity against eight fluconazole-resistant fungi with a MIC80 of 1-16 μg/ml[1].
CYP51-IN-22 (2-8×MIC, 0-24 h) exhibits fungicidal activity in a dose-dependent manner against C. parapsilosis: The longer the time, the higher the concentration, and the better the fungicidal activity[1].
CYP51-IN-22 (0-32 ml, 6 h) shows effectiveanti-biofilm inhibition activity in the biofilm growth stage of C. glabrata and C. neoformans[1].
CYP51-IN-22 (2-8 ml, 4 h) can inhibit the phase transition of C. albicans[1].
CYP51-IN-22 (10 μM, 4 h) has no significant toxicity effect on HUVEC (human umbilical vein endothelial cell line) and SH-SY5Y (neuroblastoma cell line) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP51-IN-22 Related Antibodies
In Vivo

CYP51-IN-22 (Compound V23) (10 mg/kg, i.p., 4 h after infection) has best drug efficacy evaluation in a mice model of invasive candidiasis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Candida parapsilosis was injected through the tail vein to establish a mouse (ICR, 4-6 weeks) candida-infection model
Dosage: 5 mg/kg, 10 mg/kg
Administration: intraperitoneal injection (i.p.) or gavage (p.o.) 4 h after infection
Result: Reduced the renal fungal load in mice and was better than the positive control fluconazole.
Dose-dependent, and the efficacy of intraperitoneal injection was better than that of oral gavage administration.
Molecular Weight

626.50

Formula

C29H30BrF2N7O2
SMILES

FC1=CC(F)=CC=C1C(CN(C)CC2=CC=C(N3CCN(C(C4=CC(Br)=CC=C4)=O)CC3)C=C2)(O)CN5C=NN=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYP51-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP51-IN-22FungalTetrazoleAntifungal activityDrug-resistantIn vivo pharmacodynamicsInhibitorinhibitorinhibit

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