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against

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7369

Inhibitors & Agonists

17

Screening Libraries

14

Fluorescent Dye

90

Biochemical Assay Reagents

385

Peptides

6

MCE Kits

157

Inhibitory Antibodies

1898

Natural
Products

7

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273

Isotope-Labeled Compounds

7

Antibodies

27

Click Chemistry

37

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137262
    Protein deglycase DJ-1 against-1

    		Dopamine Receptor Neurological Disease
    Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research .
    Protein deglycase DJ-1 against-1
  • HY-116536
    N-3-Oxo-tetradecanoyl-L-homoserine lactone

    oxo-C14-HSL

    		 Bacterial Infection
    N-3-Oxo-tetradecanoyl-L-homoserine lactone (oxo-C14-HSL) is a rhizobacterial inducer and can improve basic defense against nematodes .
    N-3-Oxo-tetradecanoyl-L-homoserine lactone
  • HY-109035
    Inarigivir soproxil
    1 Publications Verification

    SB9200; GS-9992

    		 HCV HBV Infection
    Inarigivir soproxil (SB9200) is an agonist of innate immunity and shows potent antiviral activity against resistant HCV variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil, an orally bioavailable proagent of SB 9000, has broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, respiratory syncytial virus and influenza and HBV .
    Inarigivir soproxil
  • HY-108707
    LY3130481
    1 Publications Verification

    		 iGluR Neurological Disease
    LY3130481 is an orally available AMPA receptor antagonist, selectively inhibiting the IC50 value of AMPA/TARP γ-8 at 65 nM. LY3130481 has anticonvulsant, antiepileptic, and pain-relieving effects .
    LY3130481
  • HY-162837
    AURKA against 1

    		Aurora Kinase Cancer
    AURKA against 1 is an inhibitor of AURKA (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3 .
    AURKA against 1
  • HY-170830
    Mtb against-1

    		Bacterial Infection
    Mtb against-1 (compound 17af) is an inhibitor of Mycobacterium tuberculosis, with IC90 values of 1.2 μM and 0.9 μM for the wild-type and LepB low-deformation strains, respectively .
    Mtb against-1
  • HY-169917
    THP-1/MV-4-11 against-1

    		Drug Derivative Cancer
    THP-1/MV-4-11 against-1 (compound 12k) is an anticancer agent with potency inhibitory against THP-1/MV/4 cells (IC50=29 nM and 98 nM, respectively). THP-1/MV-4-11 against-1 is one of 5-substituted thiazolyl urea derivatives, can be used in leukemic diseases research .
    THP-1/MV-4-11 against-1
  • HY-173049
    2N4R Tau/α-Syn against-1

    		α-synuclein Neurological Disease
    2N4R Tau/α-Syn against-1 (Compound 4d) targets α-synuclein and tau protein, inhibits the fibrillation and oligomer formation of α-synuclein and tau proteins, exhibits disaggregation activity on Aβ fibers. 2N4R Tau/α-Syn against-1 can be used in research of Parkinson's disease and Alzheimer's disease .
    2N4R Tau/α-Syn against-1
  • HY-148205
    Trypanothione

    		Drug Derivative Others
    Trypanothione is a bis-glutathionyl derivative, found in trypanosomatids. Trypanothione shows the protection against oxidative stress .
    Trypanothione
  • HY-165272
    Antibiotic SF-2132

    		Bacterial Antibiotic Infection
    Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .
    Antibiotic SF-2132
  • HY-N12763
    Sodium new houttuyfonate

    SNH

    		 Bacterial Renin Inflammation/Immunology
    Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .
    Sodium new houttuyfonate
  • HY-161261
    SARS-CoV-2-IN-81

    		AAK1 SARS-CoV Infection
    SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC50 value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection .
    SARS-CoV-2-IN-81
  • HY-P5117
    TAT-CIRP

    		Toll-like Receptor (TLR) Neurological Disease
    TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .
    TAT-CIRP
  • HY-N11434
    Anisocoumarin H

    		Fungal Infection
    Anisocoumarin H is a coumarin that exhibits antifungal activity. Anisocoumarin H shows the activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs of 62.5 µg/mL .
    Anisocoumarin H
  • HY-145865
    c-Met/MEK1/Flt-3-IN-1

    		Apoptosis Cancer
    Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase .
    c-Met/MEK1/Flt-3-IN-1
  • HY-124814
    C215

    		Bacterial Infection
    C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .
    C215
  • HY-109706
    (Rac)-CPI-098

    		Bacterial Fungal Infection
    (Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans .
    (Rac)-CPI-098
  • HY-N14876
    20-Deoxysalinomycin

    		Bacterial Infection
    20-Deoxysalinomycin is mainly against Gram-positive bacteria, especially against coccidia of poultry .
    20-Deoxysalinomycin
  • HY-N12681
    Phoslactomycin A

    		Fungal Infection
    Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin A
  • HY-119206
    Sulbenicillin

    		Antibiotic Others
    Sulbenicillin is an antibiotic that, in a study of its activity against Pseudomonas aeruginosa infection in mice, showed differences in activity against certain strains compared to other antibiotics, and activity against gentamicin-resistant strains was affected by the strain's own resistance.
    Sulbenicillin
  • HY-10337
    Brivanib
    3 Publications Verification

    BMS-540215

    		 VEGFR Autophagy Cancer
    Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β .
    Brivanib
  • HY-N14543
    Olivomycin A

    		Bacterial Infection
    Olivomycin A has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .
    Olivomycin A
  • HY-101128
    Bicyclomycin benzoate
    2 Publications Verification

    FR2054

    		 Bacterial Antibiotic Infection
    Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.
    Bicyclomycin benzoate
  • HY-N12679
    Phoslactomycin D

    		Fungal Infection
    Phoslactomycin D has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin D
  • HY-N12680
    Phoslactomycin B

    		Fungal Infection
    Phoslactomycin B has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin B
  • HY-N12676
    Phoslactomycin E

    		Fungal Infection
    Phoslactomycin E has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin E
  • HY-N12675
    Phoslactomycin F

    		Fungal Infection
    Phoslactomycin F has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin F
  • HY-N14360
    Megovalicin H

    		Bacterial Infection
    Megovalicin H has an effect against subtilis and E.coli, and it also has the effect against Pseudomonas aeruginosa .
    Megovalicin H
  • HY-N12682
    Phoslactomycin C

    		Fungal Infection
    Phoslactomycin C has weak effect against Gram-positive bacteria, but has strong effect against fungi .
    Phoslactomycin C
  • HY-144217
    SKLB-197

    		ATM/ATR Cancer
    SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
    SKLB-197
  • HY-16678
    Helioxanthin

    		HBV HCV Infection
    Helioxanthin (ACH126447) has in vitro antiviral activity with an EC50 of 1 μM against HBV and is also active against flaviviruses.
    Helioxanthin
  • HY-W439855
    10-Norparvulenone

    		Influenza Virus Bacterial Antibiotic Infection
    10-Norparvulenone is an antibiotic that fights against influenza viruses and has antibacterial activity against E. coli .
    10-Norparvulenone
  • HY-N14724
    Olivomycin C

    		Bacterial Infection
    Olivomycin C has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .
    Olivomycin C
  • HY-125419
    Amythiamicin B

    		Antibiotic Parasite Bacterial Infection
    Amythiamicin B is a trisubstituted pyridine thiopeptide with antibiotic properties against Gram-positive bacteria and activity against Plasmodium falciparum .
    Amythiamicin B
  • HY-N14235
    Megovalicin G

    		Bacterial Infection
    Megovalicin G has an effect against Bacillus Subtilis and Escherichia coli, and it also has the effect against Pseudomonas aeruginosa .
    Megovalicin G
  • HY-121347
    Enterocin

    Vulgamycin

    		 Antibiotic Bacterial Inflammation/Immunology
    Enterocin, an antibiotic, has static activities against gram-positive and gram-negative bacteria and no activity against fungi and yeast .
    Enterocin
  • HY-N15036
    Olivomycin D

    		Bacterial Infection
    Olivomycin D has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .
    Olivomycin D
  • HY-N14723
    Olivomycin B

    		Bacterial Infection
    Olivomycin B has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .
    Olivomycin B
  • HY-N14229
    Megovalicin D

    		Bacterial Infection
    Megovalicin D has an effect against Bacillus Subtilis and Escherichia coli, and it also has the effect against Pseudomonas aeruginosa .
    Megovalicin D
  • HY-126461
    Salazinic acid

    		Bacterial Fungal Infection
    Salazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium .
    Salazinic acid
  • HY-N14302
    44-Homooligomycin A

    		Antibiotic Bacterial Infection Cancer
    44-HomooIigomycin A is an antitumor antibiotic. 44-Homooligomycin A has activity against fungi such as Aspergillus, Penicillium and Fusarium, but not against yeast and bacteria. 44-Homooligomycin A has moderate anti-tumor activity against Colon 26 in vivo .
    44-Homooligomycin A
  • HY-10336
    Brivanib (alaninate)
    3 Publications Verification

    BMS-582664

    		 VEGFR Autophagy Cancer
    Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ .
    Brivanib (alaninate)
  • HY-P5592A
    Temporin B acetate

    		Bacterial Infection
    Temporin B acetate is an antimicrobial peptide against Gram-positive bacteria. Temporin B acetate is less active against Gram-negative bacteria .
    Temporin B acetate
  • HY-N14488
    Nemotinic acid

    		Bacterial Fungal Infection
    Nemotinic acid has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .
    Nemotinic acid
  • HY-N14487
    Nemotin

    		Bacterial Fungal Infection
    Nemotin has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .
    Nemotin
  • HY-106590
    Saccharocin

    Antibiotic KA 5685

    		 Bacterial Infection
    Saccharocin (Antibiotic KA 5685) is effective against Gram-positive and negative bacteria, and also against aminoglycoside antibiotic-resistant bacteria .
    Saccharocin
  • HY-P5592
    Temporin B

    		Bacterial Infection
    Temporin B is an antimicrobial peptide against Gram-positive bacteria. Temporin B is less active against Gram-negative bacteria .
    Temporin B
  • HY-N13885
    Amythiamicin A

    		Antibiotic Bacterial Parasite Infection
    Amythiamicin A is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .
    Amythiamicin A
  • HY-U00160
    SP187
    3 Publications Verification

    MON-​DNJ; UV4

    		 Flavivirus Dengue Virus Infection
    SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
    SP187
  • HY-N14305
    44-Homooligomycin B

    		Antibiotic Bacterial Infection Cancer
    44-HomooIigomycin B is an antitumor antibiotic. 44-Homooligomycin B has activity against fungi such as Aspergillus, Penicillium and Fusarium, but not against yeast and bacteria. 44-Homooligomycin B has moderate anti-tumor activity against Colon 26 in vivo .
    44-Homooligomycin B

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