2. Others Antibody-drug Conjugate/ADC Related
  3. Drug Derivative ADC Payload
  4. Camptothecin derivative-3

Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research.

For research use only. We do not sell to patients.

Camptothecin derivative-3

Camptothecin derivative-3 Chemical Structure

CAS No. : 2378619-11-3

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Camptothecin derivative-3 Related Antibodies

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Description

Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research[1].

Molecular Weight

467.45

Formula

C24H22FN3O6
CAS No.
SMILES

CC[C@@]1(O)C2=C(COC1=O)C(N(CC3=C(C4=CC(C)=C(C=C4N=C35)F)CNC(CO)=O)C5=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 3.85 mg/mL (8.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1393 mL 10.6963 mL 21.3927 mL
5 mM 0.4279 mL 2.1393 mL 4.2785 mL
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1393 mL 10.6963 mL 21.3927 mL 53.4817 mL
5 mM 0.4279 mL 2.1393 mL 4.2785 mL 10.6963 mL
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Camptothecin derivative-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camptothecin derivative-32378619-11-3Camptothecin derivative3Camptothecin derivative 3Drug DerivativeADC PayloadDrug derivativeADC CytotoxinCamptothecinADCsHSC-2Namalwa/luc cellsInhibitorinhibitorinhibit

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