2. Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Interleukin Related NO Synthase Endogenous Metabolite ERK
  4. Gluconate Calcium

Gluconate Calcium  (Synonyms: Calcium D-gluconate; Gluconic acid hemicalcium salt)

Cat. No.: HY-B1092 Purity: ≥98.0%
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Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury.

For research use only. We do not sell to patients.

Gluconate Calcium

Gluconate Calcium Chemical Structure

CAS No. : 299-28-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Gluconate Calcium:

Gluconate Calcium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury[1][2][3][4][5][6][7].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Gluconate Calcium (0.5-3 mM; 5 min) inhibits thrombin-induced arachidonic acid peroxidation and superoxide anion production in platelets, reduces platelet protein oxidation/nitration, and decreases carbonyl group generation, thiol oxidation, and nitrotyrosine formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gluconate Calcium Related Antibodies
In Vivo

Gluconate Calcium (50 g/kg of basal diet; orally; 33 weeks) increases the cecal butyrate concentration in rats and reduces the tumor incidence and the average number of tumors in rats with induced colorectal cancer[2].
Gluconate Calcium (50 mg/kg body weight; once a day for 5 weeks) regulates the changes in hematological parameters induced by Dimethylhydrazine (HY-W460407) in mice, reduces the levels of lipid peroxidation and nitric oxide (NO) in colon tissues, and improves the pathological changes of colon tissues[3].
Gluconate sodium (2500 ppm; in diet; p.o.; 15 days) increases the average daily gain of weaned piglets, reduces the feed-to-gain ratio, alleviates the intestinal injury induced by recombinant Escherichia coli, and improves the intestinal morphology[4].
Gluconate sodium (Calcium gluconate; 50 mg/kg; p.o.; 84 days) alleviates the symptoms of osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats, and inhibits joint stiffness and cartilage damage[5].
Gluconate sodium (Calcium gluconate; 12.5-50 mg/kg; i.p.; 30 min after modeling) alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice, and inhibits the infiltration of inflammatory cells and the release of inflammatory cytokines[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

216.20

Formula

C6H12O7.1/2Ca
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O.[1/2Ca]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (92.51 mM; Need ultrasonic)

DMSO : 1 mg/mL (4.63 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6253 mL 23.1267 mL 46.2535 mL
5 mM 0.9251 mL 4.6253 mL 9.2507 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.6253 mL 23.1267 mL 46.2535 mL 115.6337 mL
H2O 5 mM 0.9251 mL 4.6253 mL 9.2507 mL 23.1267 mL
10 mM 0.4625 mL 2.3127 mL 4.6253 mL 11.5634 mL
15 mM 0.3084 mL 1.5418 mL 3.0836 mL 7.7089 mL
20 mM 0.2313 mL 1.1563 mL 2.3127 mL 5.7817 mL
25 mM 0.1850 mL 0.9251 mL 1.8501 mL 4.6253 mL
30 mM 0.1542 mL 0.7709 mL 1.5418 mL 3.8545 mL
40 mM 0.1156 mL 0.5782 mL 1.1563 mL 2.8908 mL
50 mM 0.0925 mL 0.4625 mL 0.9251 mL 2.3127 mL
60 mM 0.0771 mL 0.3854 mL 0.7709 mL 1.9272 mL
80 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4454 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gluconate Calcium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gluconate299-28-5Calcium D-gluconate Gluconic acid hemicalciumInterleukin RelatedNO SynthaseEndogenous MetaboliteERKILNitric oxide synthasesNOSExtracellular signal regulated kinasesratscolorectal cancerintestinal injuryEscherichia coliosteoarthritislung injuryplateletsInhibitorinhibitorinhibit

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