2. Metabolic Enzyme/Protease Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway
  3. Endogenous Metabolite NO Synthase Interleukin Related ERK
  4. Gluconate sodium

Gluconate sodium  (Synonyms: D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt)

Cat. No.: HY-B1092A Purity: ≥98.0%
SDS
COA
Handling Instructions Technical Support

Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.

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Gluconate sodium Chemical Structure

Gluconate sodium Chemical Structure

CAS No. : 527-07-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Gluconate sodium:

Gluconate sodium Related Antibodies

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  • Biological Activity

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Description

Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury[1][2][3][4][5][6][7].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Gluconate sodium (0.5-3 mM; 5 min) inhibits thrombin-induced arachidonic acid peroxidation and superoxide anion production in platelets, reduces platelet protein oxidation/nitration, and decreases carbonyl group generation, thiol oxidation, and nitrotyrosine formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gluconate sodium Related Antibodies
In Vivo

Gluconate sodium (50 g/kg of basal diet; orally; 33 weeks) increases the cecal butyrate concentration in rats and reduces the tumor incidence and the average number of tumors in rats with induced colorectal cancer[2].
Gluconate sodium (50 mg/kg body weight; once a day for 5 weeks) regulates the changes in hematological parameters induced by Dimethylhydrazine (HY-W460407) in mice, reduces the levels of lipid peroxidation and nitric oxide (NO) in colon tissues, and improves the pathological changes of colon tissues[3].
Gluconate sodium (2500 ppm; in diet; p.o.; 15 days) increases the average daily gain of weaned piglets, reduces the feed-to-gain ratio, alleviates the intestinal injury induced by recombinant Escherichia coli, and improves the intestinal morphology[4].
Gluconate sodium (Calcium gluconate; 50 mg/kg; p.o.; 84 days) alleviates the symptoms of osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats, and inhibits joint stiffness and cartilage damage[5].
Gluconate sodium (Calcium gluconate; 12.5-50 mg/kg; i.p.; 30 min after modeling) alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice, and inhibits the infiltration of inflammatory cells and the release of inflammatory cytokines[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (4-6 weeks); acute lung injury model induced by lipopolysaccharide[6]
Dosage: 12.5, 25, 50 mg/kg
Administration: Intraperitoneally injected, 30 min after modeling
Result: Inhibited airway inflammatory injury and the release of inflammatory cytokines such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid.
Inhibited ERK phosphorylation, protecting the mouse airway from LPS-induced inflammatory response.
Clinical Trial
Molecular Weight

218.14

Formula

C6H11NaO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (458.42 mM)

DMSO : 1 mg/mL (4.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5842 mL 22.9211 mL 45.8421 mL
5 mM 0.9168 mL 4.5842 mL 9.1684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (229.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB) HNMR (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.5842 mL 22.9211 mL 45.8421 mL 114.6053 mL
H2O 5 mM 0.9168 mL 4.5842 mL 9.1684 mL 22.9211 mL
10 mM 0.4584 mL 2.2921 mL 4.5842 mL 11.4605 mL
15 mM 0.3056 mL 1.5281 mL 3.0561 mL 7.6404 mL
20 mM 0.2292 mL 1.1461 mL 2.2921 mL 5.7303 mL
25 mM 0.1834 mL 0.9168 mL 1.8337 mL 4.5842 mL
30 mM 0.1528 mL 0.7640 mL 1.5281 mL 3.8202 mL
40 mM 0.1146 mL 0.5730 mL 1.1461 mL 2.8651 mL
50 mM 0.0917 mL 0.4584 mL 0.9168 mL 2.2921 mL
60 mM 0.0764 mL 0.3820 mL 0.7640 mL 1.9101 mL
80 mM 0.0573 mL 0.2865 mL 0.5730 mL 1.4326 mL
100 mM 0.0458 mL 0.2292 mL 0.4584 mL 1.1461 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gluconate sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gluconate527-07-1D-Gluconic acid Sodium D-gluconateD-GluconateEndogenous MetaboliteNO SynthaseInterleukin RelatedERKNitric oxide synthasesNOSILExtracellular signal regulated kinasesratscolorectal cancerintestinal injuryEscherichia coliosteoarthritislung injuryplateletsInhibitorinhibitorinhibit

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