2. Anti-infection
  3. Bacterial
  4. Bezlotoxumab

Bezlotoxumab  (Synonyms: BLA761046; MBL-CDB1; MDX-1388)

Cat. No.: HY-P9929 Purity: ≥95.0%
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Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention.

For research use only. We do not sell to patients.

CAS No. : 1246264-45-8

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Based on 1 publication(s) in Google Scholar

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Bezlotoxumab Related Antibodies

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1 Publications Citing Use of MCE Bezlotoxumab

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  • Purity & Documentation

  • References

  • Customer Review

Description

Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

toxin B
In Vitro

Bezlotoxumab (100 μg/mL, 18 h pre-treatment) neutralizes TcdB-induced TER reduction in Caco-2 and MOCK cell monolayers[1].
Bezlotoxumab (100 μg/mL, 18 h pre-treatment) shows increased transport to the apical chamber of Caco-2 cells with rising TcdB concentration[1].
Bezlotoxumab (100 μg/mL, 18 h pre-treatment) inhibits TcdB-induced TER decrease in T84 cell monolayers, with Fc-independent neutralizing effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bezlotoxumab Related Antibodies
In Vivo

Bezlotoxumab (250 μg/mouse, i.p., 1 day pre-infection) improves survival of both WT and FcRn-/- C57BL/6 mice in primary CDI model, combined with Actoxumab (HY-P99277)[1].
Bezlotoxumab (50 mg/kg, s.c., q.d. for 4 days) enhances survival and reduces symptoms in 100 g male Syrian hamsters with CDI combined with Actoxumab[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female C57BL/6 wild-type or FcRn knockout mice[1]
Dosage: 250 μg/mouse
Administration: i.p., 1 day pre-infection
Result: Improved the survival rate of both wild-type and FcRn knockout mice.
Reduced the recurrence of CDI.
Animal Model: 100 g male Syrian hamsters[1]
Dosage: 50 mg/kg
Administration: s.c., q.d. for 4 days
Result: Improved the survival rate.
Clinical Trial
Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.54 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Bezlotoxumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Bezlotoxumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bezlotoxumab1246264-45-8BLA761046 MBL-CDB1 MDX-1388BLA 761046BLA-761046MDX1388MDX 1388MDX-1388BacterialC. difficiletoxins Btoxins Aintestinal epithelialcolitisInhibitorinhibitorinhibit

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