2. Metabolic Enzyme/Protease Apoptosis
  3. Fatty Acid Synthase (FASN) Apoptosis Bcl-2 Family
  4. QNX-10

QNX-10 is a fatty acid synthase (FASN) inhibitor (IC50 = 0.7 μM) with anticancer activity. QNX-10 exhibits potent FASN inhibition and cytotoxicity against colorectal and breast cancer cells. QNX-10 induces apoptosis and cell cycle arrest in S phase by upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-xL. QNX-10 can be used to investigate anticancer therapies targeting FASN enzymes.

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QNX-10 Chemical Structure

QNX-10 Chemical Structure

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QNX-10 Related Antibodies

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Description

QNX-10 is a fatty acid synthase (FASN) inhibitor (IC50 = 0.7 μM) with anticancer activity. QNX-10 exhibits potent FASN inhibition and cytotoxicity against colorectal and breast cancer cells. QNX-10 induces apoptosis and cell cycle arrest in S phase by upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-xL. QNX-10 can be used to investigate anticancer therapies targeting FASN enzymes[1].

IC50 & Target[1]

Bax

 

Bcl-xL

 

In Vitro

QNX-10 (0-10 μM, 48 h) exhibits cytotoxicity against HCT-116, Caco-2, and MCF-7 cells with IC50 of 1.5 μM, 2.1 μM, and 1.8 μM, respectively, and has no toxicity to HEK-293 cells, with an IC50 of 30.4 μM[1].

QNX-10 (0.5-2.5 μM, 48 h) inhibits cell cycle progression by inducing S phase cell cycle arrest in HCT-116 cells[1].

QNX-10 (0.5-2.5 μM) increases Bax and decreased Bcl-xL and FASN levels, exhibiting dose-dependent apoptotic properties in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QNX-10 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 μM, 1.5 μM , 2.5 μM
Incubation Time: 48 h
Result: Induced cell cycle arrest in S phase, resulting in 23.3% and 28.6% accumulation of the population in S phase at 1.5 μM and 2.5 μM, respectively, and increased the G2/M population by 27.5% and 29.4% after 1.5 μM and 2.5 μM QNX-10 exposure, respectively.

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 μM, 1.5 μM , 2.5 μM
Incubation Time: 48 h
Result: Increased the number of cell death cells, induced cell death in 15.4% of the cell population (10.93% apoptotic cells + 4.47% necrotic cells) at 0.5 μM, increased the dead cell population to 39.2% (31.6% apoptotic cells + 7.6% necrotic cells) at 1.5 μM, and induced cell death to 61.1% at 2.5 μM, of which 49.73% of the cells underwent apoptosis and 11.37% underwent necrosis.
Molecular Weight

434.46

Formula

C24H23FN4O3
SMILES

FC1=CC=C(C2=CN=C(C=C(C(N3CCN(C(C4OCCC4)=O)CC3)=O)C=C5)C5=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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QNX-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QNX-10QNX10QNX 10Fatty Acid Synthase (FASN)ApoptosisBcl-2 FamilyInhibitorHCT-116 cellsAnti-cancerinhibitorinhibit

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