2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. ALD1613

ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH). ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels.

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ALD1613 Chemical Structure

ALD1613 Chemical Structure

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ALD1613 Related Antibodies

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Description

ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH). ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
SMILES

[ALD1613]
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ALD1613 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALD1613ALD 1613ALD-1613Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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