2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Dabogratinib

Dabogratinib (GMP) is Dabogratinib (HY-159642) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Dabogratinib (GMP) is an orally active, selective inhibitor for FGFR3 with an IC50 of 11 nM. Dabogratinib (GMP) exhibits antitumor efficacy against urothelial cancers and solid tumors.

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Dabogratinib

Dabogratinib Chemical Structure

CAS No. : 2800223-30-5

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Dabogratinib Related Antibodies

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Description

Dabogratinib (GMP) is Dabogratinib (HY-159642) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Dabogratinib (GMP) is an orally active, selective inhibitor for FGFR3 with an IC50 of 11 nM. Dabogratinib (GMP) exhibits antitumor efficacy against urothelial cancers and solid tumors[1].

IC50 & Target

FGFR3

11 nM (IC50)

FGFR2

157 nM (IC50)

FGFR1

278 nM (IC50)

FGFR4

405 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
DMS-114 IC50
205 nM
Compound: 22
Inhibition of cell viability in human DMS-114 cells harboring FGFR1-amplification incubated for 72 to 120 hrs by Cell Titer Glo assay
Inhibition of cell viability in human DMS-114 cells harboring FGFR1-amplification incubated for 72 to 120 hrs by Cell Titer Glo assay
[PMID: 39258897]
KG-1 IC50
109 nM
Compound: 22
Inhibition of cell viability in human KG-1 cells harboring FGFR1-fusion incubated for 72 to 120 hrs by Cell Titer Glo assay
Inhibition of cell viability in human KG-1 cells harboring FGFR1-fusion incubated for 72 to 120 hrs by Cell Titer Glo assay
[PMID: 39258897]
RT-4 IC50
10 nM
Compound: 22
Inhibition of cell viability in human RT-4 cells harboring FGFR3/TACC3 fusion incubated for 72 to 120 hrs by Cell Titer Glo assay
Inhibition of cell viability in human RT-4 cells harboring FGFR3/TACC3 fusion incubated for 72 to 120 hrs by Cell Titer Glo assay
[PMID: 39258897]
Clinical Trial
Molecular Weight

559.47

Formula

C25H24Cl2N6O3S
CAS No.
SMILES

O=S(N(C1)CC1(C2)CN2C(N=C3)=CC=C3C4=NNC5=CC=C(O[C@H](C)C6=C(Cl)C=NC=C6Cl)C=C54)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dabogratinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dabogratinib (GMP)2800223-30-5FGFRFibroblast growth factor receptorBa/F3orally activeselectiveInhibitorinhibitorinhibit

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