2. Apoptosis
  3. Apoptosis Bcl-2 Family
  4. Apoptosis inducer 39

Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer.

For research use only. We do not sell to patients.

Apoptosis inducer 39 Chemical Structure

Apoptosis inducer 39 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Apoptosis inducer 39 Related Antibodies

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer[1].

IC50 & Target[1]

Bcl-2

 

In Vitro

Apoptosis inducer 39 (Compound Y22) (5-40 μM, 0-24 h) decreases the number of MDA-MB-231 cells and causes the cells to shrink and form apoptotic vesicles[1].
Apoptosis inducer 39 (5-20 μM, 24 h) significantly inhibits cell migration and exerts the anti-tumor activity by inducing apoptosis in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 39 Related Antibodies

Cell Migration Assay [1]

Cell Line: MDA-MB-231 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: Inhibited cell migration in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: Induced apoptosis in a concentration-dependent manner.
Increased the percentage of apoptotic cells from 3.97 % to 58.6 %.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: The pro-apoptotic protein Bax was significantly up-regulated and the expression of the antiapoptotic protein Bcl-2 was down-regulated.
Molecular Weight

443.17

Formula

C16H10BrF3N4O3
SMILES

O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Apoptosis inducer 39 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 39Apoptosis inducer39Apoptosis inducer-39ApoptosisBcl-2 Family4-AminoquinazolineSynthesisAntitumor activitybreast cancerlung cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Apoptosis inducer 39
Cat. No.:
HY-174992
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.