2. Anti-infection
  3. Antibiotic Bacterial
  4. Ranbezolid

Ranbezolid (RBx7644 free base) is an orally active, oxazolidinone antibiotic against Gram-positive and Gram-negative anaerobes including Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis. Ranbezolid can inhibit the 50s ribosomal subunit with a IC50 of 17 μM for bacterial ribosomes. Ranbezolid interferes cell wall and lipid synthesis. Ranbezolid can rapidly kill bacteria, significantly reduce bacterial load, and has better cardiovascular safety. Ranbezolid can be used for the study of antibiotics for anaerobic bacteria.

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Ranbezolid Chemical Structure

Ranbezolid Chemical Structure

CAS No. : 392659-38-0

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Ranbezolid Related Antibodies

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Description

Ranbezolid (RBx7644 free base) is an orally active, oxazolidinone antibiotic against Gram-positive and Gram-negative anaerobes including Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis. Ranbezolid can inhibit the 50s ribosomal subunit with a IC50 of 17 μM for bacterial ribosomes. Ranbezolid interferes cell wall and lipid synthesis. Ranbezolid can rapidly kill bacteria, significantly reduce bacterial load, and has better cardiovascular safety. Ranbezolid can be used for the study of antibiotics for anaerobic bacteria[1][2][3].

In Vitro

Ranbezolid (1 μg/mL) can effectively inhibit protein synthesis in S.aureus as well as in S. epidermidis, and additionally suppress the cell wall and lipid synthesis of Staphylococcus epidermidis[1].
Ranbezoild (1-8 μg/mL) can cause concentration-dependent damage to the cell membrane of S. epidermidis[1].
Ranbezoild exhibits a IC50 value of 17 μM for bacterial ribosomes and safety index of 865[1].
Ranbezolid exhibits the MICs against the anaerobic strains of B. fragilis, B. vulgatus, B. thetaiotaomicron, C. perfringens, C. difficile and P. magnus were 0.06, 0.015, 0.06, 0.06, 0.03 and 0.015 μg/mL, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ranbezolid Related Antibodies
In Vivo

Ranbezoild (100 mg/kg, p.o., twice daily for 5 days) shows excellent antibacterial activity against B. fragilis in murine foreign-body infection model[2].
Ranbezoild (≤ 50 mg/kg, p.o., single dose) does not significantly enhance the blood pressure-raising effect of Tyramine (HY-W007606) within the therapeutic dose range in the spontaneous hypertension model of rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine foreign-body infection with Bacteroides fragilis established in swiss albino mice of either sex weighing 20 ± 2 g[2]
Dosage: 100 mg/kg
Administration: Oral administration (p.o.), twice daily, for 5 days
Result: Displayed 5.39log10 reductions.
Animal Model: Pressor response model established in male Wistar rats (250-350 g)[3]
Dosage: 15, 50 and 100mg/kg
Administration: Oral administration (p.o.), single dose
Result: Increased mean arterial pressure by 10, 11, 14 mm Hg (15, 50 and 100 mg/kg) with 5 mg/kg tyramine.
Molecular Weight

461.44

Formula

C21H24FN5O6
CAS No.
SMILES

CC(NC[C@H]1CN(C2=CC=C(N3CCN(CC4=CC=C([N+]([O-])=O)O4)CC3)C(F)=C2)C(O1)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ranbezolid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranbezolid392659-38-0RBx7644RBx 7644RBx-7644AntibioticBacterialCABPStaphylococcus aureusStaphylococcus epidermidisStreptococcus pneumoniaeHaemophilus influenzaeantibacterialInhibitorinhibitorinhibit

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