2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. PF-06761281

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively.

For research use only. We do not sell to patients.

PF-06761281 Chemical Structure

PF-06761281 Chemical Structure

CAS No. : 1854061-19-0

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10 mM * 1 mL in Water In-stock
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Based on 1 publication(s) in Google Scholar

PF-06761281 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively[1].

IC50 & Target

IC50: 0.51 µM (HEKNaCT), 13.2 µM (HEKNaDC1), 14.1 µM (HEKNaDC3)[1]
In Vitro

PF-06761281 (Compound 4a) inhibits citrate uptake with IC50 values of 0.12, 0.21 and 0.74 µM in rat, mouse and human Heps[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06761281 Related Antibodies
Molecular Weight

283.28

Formula

C13H17NO6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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PF-06761281 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-067612811854061-19-0PF06761281PF 06761281Sodium ChannelNa channelsNa+ channelsSLC13A5NaCTcitrate uptakeHeporally activeInhibitorinhibitorinhibit

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