2. Anti-infection
  3. Bacterial
  4. K11

K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

K11 Chemical Structure

K11 Chemical Structure

CAS No. : 1398109-79-9

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Based on 1 publication(s) in Google Scholar

K11 Related Antibodies

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Description

K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability[1].

Molecular Weight

2493.09

Formula

C123H198N32O23
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Lys-Trp-Lys-Ser-Phe-Ile-Lys-Lys-Leu-Thr-Lys-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-NH2
Sequence Shortening

KWKSFIKKLTKKFLHSAKKF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (40.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4011 mL 2.0055 mL 4.0111 mL
5 mM 0.0802 mL 0.4011 mL 0.8022 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4011 mL 2.0055 mL 4.0111 mL 10.0277 mL
5 mM 0.0802 mL 0.4011 mL 0.8022 mL 2.0055 mL
10 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
15 mM 0.0267 mL 0.1337 mL 0.2674 mL 0.6685 mL
20 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5014 mL
25 mM 0.0160 mL 0.0802 mL 0.1604 mL 0.4011 mL
30 mM 0.0134 mL 0.0669 mL 0.1337 mL 0.3343 mL
40 mM 0.0100 mL 0.0501 mL 0.1003 mL 0.2507 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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K11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K111398109-79-9K 11K-11BacterialantimicrobialpeptideantibacterialMDRXDRInhibitorinhibitorinhibit

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