2. GPCR/G Protein Immunology/Inflammation MAPK/ERK Pathway Membrane Transporter/Ion Channel Neuronal Signaling
  3. CCR CXCR p38 MAPK JNK Calcium Channel
  4. Catenarin

Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].

For research use only. We do not sell to patients.

Catenarin Chemical Structure

Catenarin Chemical Structure

CAS No. : 476-46-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Catenarin Related Antibodies

Top Publications Citing Use of Products

View All CCR Isoform Specific Products:

View All Isoforms
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

View All CXCR Isoform Specific Products:

View All Isoforms
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].

In Vitro

Catenarin (0-2.5 μg/mL, 1 h) inhibits CCR5 (IC50 = 0.24 μg/mL) mediated chemotaxis in JK-EF1α-CCR5 cells and CXCR4 (IC50 = 0.46 μg/mL) mediated chemotaxis in Jurkat cells[1].

Catenarin (1-5 μg/mL, 1 h) inhibits calcium mobilization in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].

Catenarin (1 μg/mL, 0-15 min) inhibits the activation of MAPK cascades in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].

Catenarin (1 μg/mL, 1 h) does not affect surface expression of CCR5 and CXCR4 receptors in JK-EF1α-CCR5 cells or Jurkat cells[1].

Catenarin (0.1-0.2 μg/mL, 0-10 h) exhibits significant inhibitory effects against Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 1 μg/mL in complex media and 0.2 μg/mL in synthetic media[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Catenarin Related Antibodies

Cell Migration Assay [1]

Cell Line: Jurkat cells and JK-EF1α-CCR5 cells
Concentration: 0.5 μg/mL
Incubation Time: 8 h
Result: Abolished the movement of Jurkat cells and JK-EF1α-CCR5 cells toward SDF-1β and MIP-1β.
Abolished Jurkat cell migration mediated by MKK6 and MKK7.

Western Blot Analysis[1]

Cell Line: Jurkat cells, JK-EF1α-CCR5 cells and JK-EF1α-CCR5 cells
Concentration: 1 μg/mL
Incubation Time:
Result: Inhibited the phosphorylation of the p38 and JNK in JK-EF1α-CCR5 and Jurkat cells in response to MIP-1β and SDF-1β.
Increased the phosphorylation of ERK1/2.
Reduced the phosphorylation of MKK6 in K-EF1α-CCR5 cells triggered by MIP-1β and Jurkat cells triggered by SDF-1β.
Decreased the phosphorylation of MKK7.
In Vivo

Catenarin (4-40 mg/kg, i.p., three times per week, 4-30 weeks) suppresses leukocyte migration, islet destruction, and T1D in NOD mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD mice (4-30 weeks)[1]
Dosage: 0.4, 4, and 20 mg/kg
Administration: i.p. three times per week for 26 weeks
Result: Reduced diabetes in the age-matched mice by 33%, 86%, and 100%.
Prevented T1D in NOD mice to a greater extent than Aspirin (acetylsalicylic acid) (HY-14654).
Showed a marginal-to-modest islet destruction and leukocyte infiltration at 4 mg/kg and over.
Reduced the level of blood glucose and HbA1C at 4 mg/kg and over.
Reduced the number of CD8+ T cells and dendritic cells.
Molecular Weight

286.24

Formula

C15H10O6
CAS No.
SMILES

O=C1C2=C(C(C3=C(C=C(C)C(O)=C13)O)=O)C(O)=CC(O)=C2
Structure Classification
Initial Source

Conoideocrella krungchingensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Catenarin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catenarin476-46-0KatenarinCCRCXCRp38 MAPKJNKCalcium ChannelCC chemokine receptorCXC chemokine receptorsC-X-C motif chemokine receptorsc-Jun N-terminal kinaseCa2+ channelsCa channelsCCR5CXCR4type 1 diabetesbacteriaJurkat cellssplenocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Catenarin
Cat. No.:
HY-N11723
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.