2. Apoptosis NF-κB Anti-infection Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation Autophagy
  3. Apoptosis NF-κB Bacterial PPAR COX NO Synthase Autophagy HSV Endogenous Metabolite
  4. Sodium propionate

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.

For research use only. We do not sell to patients.

Sodium propionate

Sodium propionate Chemical Structure

CAS No. : 137-40-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium propionate:

Sodium propionate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sodium propionate

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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nNOS iNOS eNOS

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HSV-1 HSV-2 HSV

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease[1][2][3][4][5][6].

IC50 & Target[1][2][3][4][5][6]

PPAR-γ

 

HSV-1

 

COX-2

 

In Vitro

Sodium propionate (10-100 mM; 24 h for viability test) inhibits viability of GBM cell lines (U-87, A-172, U-138) in a concentration-dependent manner, induces apoptosis and autophagy in U-87 cells[1].
Sodium propionate (1-10 μM) shows potential anti-oxidant effect in J774-A1 cell cultures stimulated with hydrogen peroxide[2].
Sodium propionate (0.1 μM-10 mM) protects SH-SY5Y neuroblastoma cells from Aβ1-42-induced neurotoxicity by inhibiting NF-κB activation, reducing iNOS/COX-2 expression and NO production[3].
Sodium propionate (100 μM-3.2 mM) inhibits differentiation of naive splenocytes into Th1/Th17 cells and promotes Treg differentiation[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium propionate Related Antibodies

Apoptosis Analysis[1]

Cell Line: U-87
Concentration: 50 mM, 100 mM
Incubation Time:
Result: Induced apoptosis.
Upregulated p53, Bax, and caspase-3 protein levels.
Downregulated Bcl-2 protein level.

Cell Autophagy Assay[1]

Cell Line: U-87
Concentration: 50 mM, 100 mM
Incubation Time:
Result: Activated autophagy.
Upregulated LC3II/I, Beclin-1, and Atg5 protein levels.
Downregulated p62 protein level.
In Vivo

Sodium propionate (30-100 mg/kg; p.o.; 2 weeks) reduces tumor growth, improves pathological features, and inhibits proliferation in BALB/c nude mice bearing U-87 GBM xenografts[1].
Sodium propionate (10-100 mg/kg; p.o.; 30 min before CAR subplantar injection) reduces Carrageenan (HY-125474)-induced paw edema and KO₂-induced pain/inflammation in Sprague-Dawley rats by inhibiting iNOS/COX-2 and enhancing antioxidant enzymes[2].
Sodium propionate (10-100 mg/kg; p.o.; 1 h and 6 h after injury) alleviates spinal cord trauma (SCI) in CD1 mice by reducing neuroinflammation, lipid peroxidation, and improving motor function [3].
Sodium propionate (500 mM; p.o. via drinking water; 3 weeks before infection to experiment end) reduces HSV-1-induced ocular stromal keratitis (SK) in C57BL/6 mice by regulating T cell balance (increasing Treg/Th1/Th17 ratio) and reducing inflammation[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude male mice (25-30 g; 6-8 weeks old) bearing U-87 GBM xenografts[1]
Dosage: 10 mg/kg, 30 mg/kg, 100 mg/kg
Administration: oral gavage, 2 weeks
Result: Decreased tumor necrosis and neutrophil infiltration.
Reduced Ki-67 (proliferation marker) expression.
Induced apoptosis and autophagy.
Clinical Trial
Molecular Weight

96.06

Formula

C3H5NaO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (2082.03 mM)

DMSO : 2 mg/mL (20.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 10.4102 mL 52.0508 mL 104.1016 mL
5 mM 2.0820 mL 10.4102 mL 20.8203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.0%

SDS (393 KB)

COA (246 KB) HNMR (221 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 10.4102 mL 52.0508 mL 104.1016 mL 260.2540 mL
5 mM 2.0820 mL 10.4102 mL 20.8203 mL 52.0508 mL
10 mM 1.0410 mL 5.2051 mL 10.4102 mL 26.0254 mL
15 mM 0.6940 mL 3.4701 mL 6.9401 mL 17.3503 mL
20 mM 0.5205 mL 2.6025 mL 5.2051 mL 13.0127 mL
H2O 25 mM 0.4164 mL 2.0820 mL 4.1641 mL 10.4102 mL
30 mM 0.3470 mL 1.7350 mL 3.4701 mL 8.6751 mL
40 mM 0.2603 mL 1.3013 mL 2.6025 mL 6.5064 mL
50 mM 0.2082 mL 1.0410 mL 2.0820 mL 5.2051 mL
60 mM 0.1735 mL 0.8675 mL 1.7350 mL 4.3376 mL
80 mM 0.1301 mL 0.6506 mL 1.3013 mL 3.2532 mL
100 mM 0.1041 mL 0.5205 mL 1.0410 mL 2.6025 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium propionate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium propionate137-40-6ApoptosisNF-κBBacterialPPARCOXNO SynthaseAutophagyHSVEndogenous MetaboliteNuclear factor-κBNuclear factor-kappaBPeroxisome proliferator-activated receptorsCyclooxygenaseNitric oxide synthasesNOSHerpes simplex virusbiochemical assayreagentInhibitorinhibitorinhibit

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