2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. Antitumor photosensitizer-9

Antitumor photosensitizer-9 is a near-infrared photosensitizer (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces ROS generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research.

For research use only. We do not sell to patients.

Antitumor photosensitizer-9 Chemical Structure

Antitumor photosensitizer-9 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antitumor photosensitizer-9 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antitumor photosensitizer-9 is a near-infrared photosensitizer (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces ROS generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research[1].

In Vitro

Antitumor photosensitizer-9 (Compound A1) (2 h) shows Light dose-related photo-toxicity against HeLa cells, with IC50s < 5.0 nM[1].
Antitumor photosensitizer-9 (2 h) shows phototoxicity (IC50s = 3.7, 3.6, 4.5, 3.7 nM) and dark cytotoxicity (IC50s = 11.5, 13.5, 12.7, 10.7 μM) in HeLa, HepG 2, B16–F10, HUVEC cells[1].
Antitumor photosensitizer-9 (5 μM, 2 h) reaches peak intracellular accumulation and mainly accumulates in the ER in HeLa cells[1].
Antitumor photosensitizer-9 (0-500 nM,2 h) induces the production of ROS under light irradiation in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor photosensitizer-9 Related Antibodies
In Vivo

Antitumor photosensitizer-9 (Compound A1) (2mg/kg, i.v., once) inhibits tumor growth and has no physiological toxicity in nude mice bearing HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c Nude mice (6-8 weeks old, 20-22 g, 24 days of PDT treatment;) bearing HeLa cells (5 × 106 cells, 0.1 mL, s.c.) [1]
Dosage: 2mg / kg
Administration: i.v., once
Result: Inhibited tumor growth, with tumor volume decreased by 78% and had no physiological toxicity, was more effective than photosensitizers Ce6 (HY-13594) and BDP4 (HY-D1452).
Molecular Weight

809.54

Formula

C44H41BIN5O2
SMILES

IC(C(C1=CC=C(C=C1)OC)=[N]2C3=NC4=C(C=C(N4B2(C#CCN(C)C)C#CCN(C)C)C5=CC=C(C=C5)OC)C6=CC=CC=C6)=C3C7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antitumor photosensitizer-9 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor photosensitizer-9Antitumor photosensitizer9Antitumor photosensitizer 9Reactive Oxygen Species (ROS)PhotosensitizerHeLa cellsNude miceInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antitumor photosensitizer-9
Cat. No.:
HY-175214
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.