2. Anti-infection Stem Cell/Wnt
  3. Bacterial Parasite Antibiotic Hedgehog
  4. Ornidazole

Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease.

For research use only. We do not sell to patients.

Ornidazole Chemical Structure

Ornidazole Chemical Structure

CAS No. : 16773-42-5

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Based on 2 publication(s) in Google Scholar

Other Forms of Ornidazole:

Ornidazole Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease[1][2][3].

In Vitro

Ornidazole exhibits inhibitory activity against anaerobic bacteria, including Bacteroides fragilis, B. melaninogenicus, fusobacteria, clostridia, Lactobacillus, and Actinomyces[2].
Ornidazole (0-1200 μg/mL, 24-72 h) inhibits the viability of mouse melanoma cell B16F10, blocks the migration ability of B16F10 cell, and induces DNA damage[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ornidazole Related Antibodies

Cell Viability Assay[3]

Cell Line: B16F10
Concentration: 0-1200 μg/mL
Incubation Time: 72 h
Result: Inhibited the cell viability.

Cell Migration Assay [3]

Cell Line: B16F10
Concentration: 0-1600 μg/mL
Incubation Time: 24 h
Result: Inhibited the cell migration.
In Vivo

Ornidazole (80 mg/kg, ip, once daily for 12 days) affects endoplasmic reticulum (ER) stress, exhibits antitumor efficacy in B16F10 xenograft mouse models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 xenograft mouse models[3]
Dosage: 80 mg/kg
Administration: ip, once daily for 12 days
Result: Reduced the tumor volume.
Clinical Trial
Molecular Weight

219.63

Formula

C7H10ClN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=NC=C([N+]([O-])=O)N1CC(CCl)O
Structure Classification
Initial Source

Propionibacterium acnes
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (455.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (45.53 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5532 mL 22.7658 mL 45.5315 mL
5 mM 0.9106 mL 4.5532 mL 9.1063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (91.06 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.58%

SDS (392 KB)

COA (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.5532 mL 22.7658 mL 45.5315 mL 113.8288 mL
5 mM 0.9106 mL 4.5532 mL 9.1063 mL 22.7658 mL
10 mM 0.4553 mL 2.2766 mL 4.5532 mL 11.3829 mL
15 mM 0.3035 mL 1.5177 mL 3.0354 mL 7.5886 mL
20 mM 0.2277 mL 1.1383 mL 2.2766 mL 5.6914 mL
25 mM 0.1821 mL 0.9106 mL 1.8213 mL 4.5532 mL
30 mM 0.1518 mL 0.7589 mL 1.5177 mL 3.7943 mL
40 mM 0.1138 mL 0.5691 mL 1.1383 mL 2.8457 mL
DMSO 50 mM 0.0911 mL 0.4553 mL 0.9106 mL 2.2766 mL
60 mM 0.0759 mL 0.3794 mL 0.7589 mL 1.8971 mL
80 mM 0.0569 mL 0.2846 mL 0.5691 mL 1.4229 mL
100 mM 0.0455 mL 0.2277 mL 0.4553 mL 1.1383 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ornidazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ornidazole16773-42-5Ro 7-0207BacterialParasiteAntibioticHedgehogInhibitorinhibitorinhibit

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