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  3. Drug Derivative
  4. anti-TNBC agent-10

anti-TNBC agent-10 is an anti-TNBC agent. anti-TNBC agent-10 shows potent anti-TNBC activity against BT549 cells (IC50 = 0.018 μM) and maintains activity against MDA-MB-231 cells (IC50 = 4.16 μM). anti-TNBC agent-10 9 demonstrates significant anti-tumor efficacy in mice bearing subcutaneous MDA-MB-231 TNBC xenografts. anti-TNBC agent-10 can be used for the study of triple-negative breast cancer (TNBC).

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anti-TNBC agent-10

anti-TNBC agent-10 Chemical Structure

CAS No. : 2923722-02-3

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anti-TNBC agent-10 Related Antibodies

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Description

anti-TNBC agent-10 is an anti-TNBC agent. anti-TNBC agent-10 shows potent anti-TNBC activity against BT549 cells (IC50 = 0.018 μM) and maintains activity against MDA-MB-231 cells (IC50 = 4.16 μM). anti-TNBC agent-10 9 demonstrates significant anti-tumor efficacy in mice bearing subcutaneous MDA-MB-231 TNBC xenografts. anti-TNBC agent-10 can be used for the study of triple-negative breast cancer (TNBC)[1].

In Vivo

anti-TNBC agent-10 9 (Analog 9) (25 mg/kg, intraperitoneal injection, quaque 1 die x 5 (Q1Dx5) for 2 weeks) demonstrates significant anti-tumor efficacy in athymic nude mice bearing subcutaneous MDA-MB-231 TNBC xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231 TNBC cells were subcutaneously implanted into the right flanks of athymic nude mice to establish a subcutaneous TNBC xenograft model[1]
Dosage: 25 mg/kg
Administration: intraperitoneal injection, Q1Dx5 for 2 weeks
Result: Achieved significant tumor growth inhibition.
Molecular Weight

337.23

Formula

C11H11F4N5O3
CAS No.
SMILES

F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(C(F)(F)F)N=C3N)=C3N=C2
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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anti-TNBC agent-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

anti-TNBC agent-102923722-02-3Drug DerivativeDrug derivativetriple-negative breast cancerBT549MDA-MB-231 cellsInhibitorinhibitorinhibit

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