Cupressuflavone

Name: Cupressuflavone
Brand: MedChemExpress
SKU: HY-N9173
Rating: 4.5 (1 reviews)

Cat. No.: HY-N9173 Purity: 99.32%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl₄-induced hepato- and nephrotoxicity in mice.

For research use only. We do not sell to patients.

Cupressuflavone Chemical Structure

CAS No. : 3952-18-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	≥ 50 μM Compound: Cupressuflavone	Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay	[PMID: 30108705]

In Vitro

Cupressuflavone (40-160 mg/kg; p.o. once daily for 5 days) exerts a beneficial effect against oxidative stress by enhancing the antioxidant defense status, reducing lipid peroxidation, and protecting against the pathological changes induced by CCl₄ in the liver and kidney tissues^[1].
Cupressuflavone (40-160 mg/kg; p.o.) inhibits paw edema by 55, 60, and 64% at the three doses of 40, 100, and 160 mg/kg, respectively in the carrageenan-induced paw edema model of inflammation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

538.46

Formula

C₃₀H₁₈O₁₀

CAS No.

3952-18-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=C5C(C(C=C(C6=CC=C(O)C=C6)O5)=O)=C(O)C=C4O)C(O)=CC(O)=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (185.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8571 mL	9.2857 mL	18.5715 mL
5 mM	0.3714 mL	1.8571 mL	3.7143 mL
10 mM	0.1857 mL	0.9286 mL	1.8571 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.32%

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Data Sheet (273 KB) SDS (252 KB)

COA (251 KB) HNMR (171 KB) CNMR (189 KB) RP-HPLC (355 KB) MS (461 KB)

Handling Instructions (2659 KB)

References

[1]. Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71. [Content Brief]

[2]. Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28. [Content Brief]

[3]. Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8571 mL	9.2857 mL	18.5715 mL	46.4287 mL
	5 mM	0.3714 mL	1.8571 mL	3.7143 mL	9.2857 mL
	10 mM	0.1857 mL	0.9286 mL	1.8571 mL	4.6429 mL
	15 mM	0.1238 mL	0.6190 mL	1.2381 mL	3.0952 mL
	20 mM	0.0929 mL	0.4643 mL	0.9286 mL	2.3214 mL
	25 mM	0.0743 mL	0.3714 mL	0.7429 mL	1.8571 mL
	30 mM	0.0619 mL	0.3095 mL	0.6190 mL	1.5476 mL
	40 mM	0.0464 mL	0.2321 mL	0.4643 mL	1.1607 mL
	50 mM	0.0371 mL	0.1857 mL	0.3714 mL	0.9286 mL
	60 mM	0.0310 mL	0.1548 mL	0.3095 mL	0.7738 mL
	80 mM	0.0232 mL	0.1161 mL	0.2321 mL	0.5804 mL
	100 mM	0.0186 mL	0.0929 mL	0.1857 mL	0.4643 mL