2. Anti-infection
  3. SARS-CoV
  4. Pomotrelvir

Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 of 24 nM for wild-type SARS-CoV-2 Mpro. Pomotrelvir inhibits viral polyprotein processing, thereby preventing viral replication. Pomotrelvir has shown broad antiviral activity against multiple SARS-CoV-2 variants (including Omicron) in cell-based experiments, and has an additive effect when combined with nucleoside analogs that target viral RNA synthesis. Pomotrelvir is primarily used for the research and development of COVID-19 antiviral drugs, especially for infections caused by SARS-CoV-2 and its variants.

For research use only. We do not sell to patients.

Pomotrelvir Chemical Structure

Pomotrelvir Chemical Structure

CAS No. : 2713437-86-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

Pomotrelvir Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pomotrelvir

  • Biological Activity

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  • References

  • Customer Review

Description

Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 of 24 nM for wild-type SARS-CoV-2 Mpro. Pomotrelvir inhibits viral polyprotein processing, thereby preventing viral replication. Pomotrelvir has shown broad antiviral activity against multiple SARS-CoV-2 variants (including Omicron) in cell-based experiments, and has an additive effect when combined with nucleoside analogs that target viral RNA synthesis. Pomotrelvir is primarily used for the research and development of COVID-19 antiviral drugs, especially for infections caused by SARS-CoV-2 and its variants[1][2].

IC50 & Target

SARS-CoV-2 (Mpro

24 nM (IC50)

In Vitro

Enzyme activity assay:
Pomotrelvir competitively inhibits SARS-CoV-2 Mpro with a Ki of 2.7 nM; it also inhibits the Mpro of other human coronaviruses (CoV-229E, CoV-OC43, etc.) with an IC50 of 61-379 nM[1].
Cell infection assay:
Pomotrelvir (23-36 nM; 48 h) significantly inhibits viral replication in SARS-CoV-2 infection or replication experiments in iPS-AT2, A549-hACE2 and Huh7 cells with an EC50 value of 23-36 nM, and is effective against clinical isolates such as Omicron[1].
Cross-resistance experiment:
Pomotrelvir significantly reduces its inhibitory activity against Mpro carrying Nirmatrelvir (HY-138687) resistance mutations (such as E166V, H172Y), while some mutations (such as L50F, T21I) does not affect its inhibitory effect[1].
Binding specificity experiment:
Pomotrelvir (100 μM) had no inhibitory effect on caspase-2, Chymotrypsin C, etc. in the human protease inhibition experiment, showing high selectivity for SARS-CoV-2 Mpro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomotrelvir Related Antibodies
Clinical Trial
Molecular Weight

455.94

Formula

C23H26ClN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C2C(C=C(N2)C(N[C@H](C(N[C@H](C#N)C[C@H]3C(NCCC3)=O)=O)CC4CC4)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1933 mL 10.9664 mL 21.9327 mL
5 mM 0.4387 mL 2.1933 mL 4.3865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1933 mL 10.9664 mL 21.9327 mL 54.8318 mL
5 mM 0.4387 mL 2.1933 mL 4.3865 mL 10.9664 mL
10 mM 0.2193 mL 1.0966 mL 2.1933 mL 5.4832 mL
15 mM 0.1462 mL 0.7311 mL 1.4622 mL 3.6555 mL
20 mM 0.1097 mL 0.5483 mL 1.0966 mL 2.7416 mL
25 mM 0.0877 mL 0.4387 mL 0.8773 mL 2.1933 mL
30 mM 0.0731 mL 0.3655 mL 0.7311 mL 1.8277 mL
40 mM 0.0548 mL 0.2742 mL 0.5483 mL 1.3708 mL
50 mM 0.0439 mL 0.2193 mL 0.4387 mL 1.0966 mL
60 mM 0.0366 mL 0.1828 mL 0.3655 mL 0.9139 mL
80 mM 0.0274 mL 0.1371 mL 0.2742 mL 0.6854 mL
100 mM 0.0219 mL 0.1097 mL 0.2193 mL 0.5483 mL
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Pomotrelvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomotrelvir2713437-86-4PBI-0451PBI0451PBI 0451SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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