2. Anti-infection
  3. HSV
  4. Adibelivir

Adibelivir (IM-250) is an orally active helicase-primase inhibitor. Adibelivir is effective against HSV infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC50: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease[1][2].

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Adibelivir

Adibelivir Chemical Structure

CAS No. : 2305750-23-4

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Adibelivir Related Antibodies

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Description

Adibelivir (IM-250) is an orally active helicase-primase inhibitor. Adibelivir is effective against HSV infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC50: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease[1][2].
In Vitro

Adibelivir (IM-25) inhibits HSV-1 (strain Cl1) and for HSV-2 (strain MS) with IC50s of 19 nM and 28 nM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adibelivir Related Antibodies
In Vivo

Adibelivir (IM-25) (150-500 mg/kg; oral; weekly intervals for 12 weeks) can inhibit subsequent relapses by intermittent treatment of infected animals for 4-7 cycles during the incubation period[1].


Adibelivir (IM-25) (10 mg/kg; oral gavage; once) blocks viral reactivation (infectious virus production) in mice[1].
IM-250 (4-10 mg/kg) significantly increases survival rate, reduces clinical scores and viral load in lungs and brains of BALB/c mice with intranasal HSV-1 lethal infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Hartley guinea pigs (250-350 g) were inoculated intravaginally with HSV-2 (MS strain)[1].
Dosage: 500 mg/kg in diet carrier [high dose chow, ∼15 mg/kg/day] or 150 mg/kg in diet carrier [low dose diet, ∼5 mg/kg/day)
Administration: Oral; weekly intervals for 12 weeks
Result: After 7 cycles (week 15) there were no further recurrences.
Animal Model: Swiss Webster (SW) outbred mice (22-25 g) were infected by dispensing 10 μL of inoculum containing HSV-1 strain 17VP16pLacZ onto each scarified corneal surface[1].
Dosage: 10 mg/kg
Administration: Oral gavage; once
Result: Blocked viral reactivation (infectious virus production) in 100% of mice.
Clinical Trial
Molecular Weight

435.51

Formula

C20H19F2N3O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C=CC(F)=C1)=C1C(C=C2)=CC=C2CC(N(C3=NC(C)=C([S@@](C)(=N)=O)S3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (287.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2962 mL 11.4808 mL 22.9616 mL
5 mM 0.4592 mL 2.2962 mL 4.5923 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2962 mL 11.4808 mL 22.9616 mL 57.4040 mL
5 mM 0.4592 mL 2.2962 mL 4.5923 mL 11.4808 mL
10 mM 0.2296 mL 1.1481 mL 2.2962 mL 5.7404 mL
15 mM 0.1531 mL 0.7654 mL 1.5308 mL 3.8269 mL
20 mM 0.1148 mL 0.5740 mL 1.1481 mL 2.8702 mL
25 mM 0.0918 mL 0.4592 mL 0.9185 mL 2.2962 mL
30 mM 0.0765 mL 0.3827 mL 0.7654 mL 1.9135 mL
40 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4351 mL
50 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1481 mL
60 mM 0.0383 mL 0.1913 mL 0.3827 mL 0.9567 mL
80 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7175 mL
100 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5740 mL
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Adibelivir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adibelivir2305750-23-4IM-250IM250IM 250HSVHerpes simplex virusHSV infection Vero cellInhibitorinhibitorinhibit

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