2. Anti-infection Membrane Transporter/Ion Channel
  3. Antibiotic Bacterial Fungal Proton Pump
  4. Bafilomycin B1

Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.

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Bafilomycin B1 Chemical Structure

Bafilomycin B1 Chemical Structure

CAS No. : 88899-56-3

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Based on 1 publication(s) in Google Scholar

Bafilomycin B1 Related Antibodies

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Description

Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets[1][2][3].

IC50 & Target

Macrolide

 

In Vitro

Bafilomycin B1 (Compound BafB1) (1 nM, 24 h) significantly inhibits the chloroquine-induced death of cerebellar granule neurons[1].
Bafilomycin B1 (Compound BafB1) (0.1-10 nM, 48 h) does not induce SH-SY5Y cell death or apoptosis at concentration ≤ 1 nM and significantly attenuates chloroquine-induced cell death with the addition of 50 μM chloroquine[2].
Bafilomycin B1 (5-10 nM) significantly inhibits the [14C]oleate incorporation into cholesteryl esters in J774 cells incubated with [14C]oleate in the presence of oxidized LDL for 3 h[3].
Bafilomycin B1 (10-40 nM) significantly inhibits the surface binding, intracellular accumulation and degradation of oxidized 125I-LDL in J774 cells incubated with oxidized 125I-LDL at 37 ℃[3].
Bafilomycin B1 (50 nM, 20 min) inhibits 74% of the degradation of the internalized oxidized 125I-LDL in J774 cells, suggesting Bafilomycin B1 inhibits the endosomal and lysosomal functions[3].
Bafilomycin B1 (50 nM, 60 min) causes a reduction of the cell surface receptors for oxidized LDL when incubated with oxidized 125I-LDL at 37 ℃[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bafilomycin B1 Related Antibodies
In Vivo

Bafilomycin B1 (Compound BafB1) (50-150 μg/mL, 24 h) shows significant protection against α-synuclein-induced dopaminergic degeneration in isogenic worms over-expressing human WT α-synuclein in dopamine neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

815.99

Formula

C44H65NO13
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
Structure Classification
Initial Source

Streptomyces halstedii K122
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (122.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2255 mL 6.1275 mL 12.2551 mL
5 mM 0.2451 mL 1.2255 mL 2.4510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.22%

SDS (251 KB)

COA (250 KB) RP-HPLC (1188 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2255 mL 6.1275 mL 12.2551 mL 30.6376 mL
5 mM 0.2451 mL 1.2255 mL 2.4510 mL 6.1275 mL
10 mM 0.1226 mL 0.6128 mL 1.2255 mL 3.0638 mL
15 mM 0.0817 mL 0.4085 mL 0.8170 mL 2.0425 mL
20 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5319 mL
25 mM 0.0490 mL 0.2451 mL 0.4902 mL 1.2255 mL
30 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
40 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7659 mL
50 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
60 mM 0.0204 mL 0.1021 mL 0.2043 mL 0.5106 mL
80 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3830 mL
100 mM 0.0123 mL 0.0613 mL 0.1226 mL 0.3064 mL
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Bafilomycin B1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bafilomycin B188899-56-3Bafilomycin B 1Bafilomycin B-1AntibioticBacterialFungalProton PumpInhibitorinhibitorinhibit

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