2. Anti-infection Apoptosis
  3. HBV Apoptosis
  4. Linvencorvir

Linvencorvir  (Synonyms: RG7907; RO7049389)

Cat. No.: HY-145579 Purity: 98.14%
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Linvencorvir (RG7907) is an orally active Hepatitis B virus core protein allosteric modulator. Linvencorvir induces Apoptosis. Linvencorvir has antiviral activity against HBV.

For research use only. We do not sell to patients.

Linvencorvir Chemical Structure

Linvencorvir Chemical Structure

CAS No. : 1808248-05-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

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Linvencorvir Related Antibodies

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Description

Linvencorvir (RG7907) is an orally active Hepatitis B virus core protein allosteric modulator. Linvencorvir induces Apoptosis. Linvencorvir has antiviral activity against HBV[1][2][3][4][5][6].

In Vitro

Linvencorvir inhibits HBV DNA replication in HepG2.2.15 cells with an EC50 of 62 nM[1].
Linvencorvir inhibits HBV DNA production in HepG2.117 cells with an EC50 of 64 nM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Linvencorvir Related Antibodies
In Vivo

Linvencorvir (6-20 mg/kg; p.o.; once daily; 8 weeks) reduces serum HBV DNA, HBsAg, and HBeAg levels in a dose-dependent manner in the adeno-associated virus-hepatitis B virus (AAV-HBV) mouse model[3].
Linvencorvir (20 mg/kg; p.o.; once daily; 70 days) significantly reduces serum HBsAg, HBeAg, and liver AAV-HBV episome levels in the adeno-associated virus-hepatitis B virus (AAV-HBV) mouse model, while inducing hepatocyte apoptosis and proliferation, accompanied by a transient increase in ALT[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (5-6 weeks old) injected with AAV-HBV to establish the AAV-HBV mouse model[4]
Dosage: 20 mg/kg
Administration: Oral gavage (p.o.), once daily for 70 days
Result: Rapidly reduced serum HBV DNA levels by ~3 log10 IU/mL by day 7.
Decreased serum HBsAg and HBeAg by 1.5 and 1.2 log10 IU/mL respectively, but with a delay compared to HBV DNA decline.
Significantly reduced the number of HBc-positive and HBsAg-positive hepatocytes on day 35, and further decreased them on day 70.
Significantly decreased intrahepatic HBV pgRNA on day 35 and further decreased it on day 70.
Reduced the amount of AAV-HBV DNA in the liver.
Increased apoptotic cells at days 14 and 35.
Clinical Trial
Molecular Weight

598.69

Formula

C29H35FN6O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCOC(C1=C(CN2C[C@]3([H])N(C(N(C3)CC(C)(C)C(O)=O)=O)CC2)N=C(C4=NC=CS4)N[C@@]1([H])C5=C(C(F)=CC=C5)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (104.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6703 mL 8.3516 mL 16.7031 mL
5 mM 0.3341 mL 1.6703 mL 3.3406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6703 mL 8.3516 mL 16.7031 mL 41.7578 mL
5 mM 0.3341 mL 1.6703 mL 3.3406 mL 8.3516 mL
10 mM 0.1670 mL 0.8352 mL 1.6703 mL 4.1758 mL
15 mM 0.1114 mL 0.5568 mL 1.1135 mL 2.7839 mL
20 mM 0.0835 mL 0.4176 mL 0.8352 mL 2.0879 mL
25 mM 0.0668 mL 0.3341 mL 0.6681 mL 1.6703 mL
30 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3919 mL
40 mM 0.0418 mL 0.2088 mL 0.4176 mL 1.0439 mL
50 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
60 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
80 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.5220 mL
100 mM 0.0167 mL 0.0835 mL 0.1670 mL 0.4176 mL
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Linvencorvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linvencorvir1808248-05-6RG7907 RO7049389RG 7907RG-7907RO7049389RO 7049389RO-7049389HBVApoptosisHepatitis B virusAAV-HBVmouseHepG2.2.15Inhibitorinhibitorinhibit

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