Palladium(Ⅱ) acetylacetonate  (Synonyms: Palladium(Ⅱ) 2,4-pentanedionate; Pd(acac)2)

Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer^[1][2][3].

Palladium(Ⅱ) acetylacetonate (72 h) shows stronger cytotoxicity than Cisplatin (HY-17394) in H460, BGC-823, HL-60, and Hela cells (IC₅₀ values in H460 cells: 4.56 μM (Palladium(Ⅱ) acetylacetonate) vs. 10.17 μM (Cisplatin))^[2].
Palladium(Ⅱ) acetylacetonate (5-20 μM; 16 h) induces apoptosis in H460 cells in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palladium(Ⅱ) acetylacetonate (1-2 mg/kg; i.p.; every 2 days; 16 days) significantly inhibits the growth of H460 tumor xenografts in athymic BALB/cA nu/nu female mice ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

304.62

C₁₀H₁₄O₄Pd

14024-61-4

Solid

Light yellow to yellow

CC(/C=C([O-])/C)=O.[Pd+2].[2]

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Cominos V, et al. Sublimation and deposition behaviour of palladium (II) acetylacetonate. The European Physical Journal-Applied Physics, 2001, 15(1): 23-33.

  [2]. Wang Y, et al. An oxygen-chelate complex, palladium bis-acetylacetonate, induces apoptosis in H460 cells via endoplasmic reticulum stress pathway rather than interacting with DNA. J Med Chem. 2013 Dec 12;56(23):9601-11.  [Content Brief]

  [3]. Özkar S, et al. Palladium(0) Nanoparticle Formation, Stabilization, and Mechanistic Studies: Pd(acac)₂ as a Preferred Precursor, [Bu₄N]₂HPO₄ Stabilizer, plus the Stoichiometry, Kinetics, and Minimal, Four-Step Mechanism of the Palladium Nanoparticle Formation and Subsequent Agglomeration Reactions. Langmuir. 2016 Apr 19;32(15):3699-716.  [Content Brief]