2. Others JAK/STAT Signaling Protein Tyrosine Kinase/RTK TGF-beta/Smad Stem Cell/Wnt Epigenetics Autophagy Apoptosis PI3K/Akt/mTOR NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage Anti-infection
  3. Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
  4. Daphnetin (Standard)

Daphnetin (Standard)  (Synonyms: 7,8-Dihydroxycoumarin (Standard))

Cat. No.: HY-N0281R
Handling Instructions Technical Support

Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

For research use only. We do not sell to patients.

Daphnetin (Standard)

Daphnetin (Standard) Chemical Structure

CAS No. : 486-35-1

Size Price Stock Quantity
5 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
10 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
25 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
200 mg   Get quote  
500 mg   Get quote  
Synthetic products have potential research and development risk.

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Based on 1 publication(s) in Google Scholar

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

178.14

Formula

C9H6O4
CAS No.
SMILES

O=C1C=CC2=CC=C(O)C(O)=C2O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Daphnetin (Standard) Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Daphnetin (Standard)486-35-17,8-Dihydroxycoumarin (Standard)Reference StandardsEGFRPKAPKCAutophagyApoptosisAMPKAktmTORReactive Oxygen Species (ROS)CaspaseBcl-2 FamilyPARPParasiteEpidermal growth factor receptorErbB-1HER1Protein kinase AProtein kinase CAMP-activated protein kinasePKBProtein kinase BMammalian target of Rapamycinpoly ADP ribose polymeraseprotein kinaseapoptosisautophagyschizontocidalinflammationA2780 cellsInhibitorinhibitorinhibit

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