2. Anti-infection
  3. Antibiotic Bacterial
  4. Colistin

Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Colistin sulfate) that retains the same biological activity.

For research use only. We do not sell to patients.

Colistin Chemical Structure

Colistin Chemical Structure

CAS No. : 1066-17-7

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Colistin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

In Vivo

Colistin (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[1]
Dosage: 16 mg/kg/day
Administration: 16 mg/kg/day, i.p.
Result: Detected apoptosis, necrosis PCNA staining in mice.
Clinical Trial
Molecular Weight

1169.50

Formula

C53H100N16O13 (for E1)
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Colistin]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (85.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8551 mL 4.2753 mL 8.5507 mL
5 mM 0.1710 mL 0.8551 mL 1.7101 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8551 mL 4.2753 mL 8.5507 mL 21.3767 mL
5 mM 0.1710 mL 0.8551 mL 1.7101 mL 4.2753 mL
10 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1377 mL
15 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
20 mM 0.0428 mL 0.2138 mL 0.4275 mL 1.0688 mL
25 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8551 mL
30 mM 0.0285 mL 0.1425 mL 0.2850 mL 0.7126 mL
40 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5344 mL
50 mM 0.0171 mL 0.0855 mL 0.1710 mL 0.4275 mL
60 mM 0.0143 mL 0.0713 mL 0.1425 mL 0.3563 mL
80 mM 0.0107 mL 0.0534 mL 0.1069 mL 0.2672 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Colistin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Colistin1066-17-7AntibioticBacterialoralpolypeptide antibioticPseudomonas aeruginosaKlebsiella pneumoniaeAcinetobacter baumanniiGram-negative bacterianephrotoxicityinfectionInhibitorinhibitorinhibit

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