2. Academic Validation
  3. Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood

Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood

  • Int Immunopharmacol. 2025 Jun 26:159:114888. doi: 10.1016/j.intimp.2025.114888.
Lei Wang 1,  Chuqiao Lai 1,  Jiahui Yu 1,  Xinyi Xu 1,  Minghui Jia 2,  Zheng Wang 1,  Yeqing Chen 1,  Qianjin Lou 1,  Qihong Tao 3,  Hao Hu 3,  Zhanqing Fu 3,  Xiaoxiao Jia 1,  Weixi Zhang 4
Affiliations

Affiliations

  • 1 Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City 325000, China.
  • 2 Zhejiang Chinese Medical University, Hangzhou City 310053, China.
  • 3 Wenzhou Medical University, Wenzhou City 325000, China.
  • 4 Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City 325000, China. Electronic address: zhangweixi112@163.com.
PMID: 40403504 DOI: 10.1016/j.intimp.2025.114888
Abstract

Food allergy (FA) pathogenesis links to intestinal dysbiosis, with Antibiotic exposure a suspected risk factor, yet mechanisms are unclear. Our study shows early life (EL) Antibiotic exposure in mice heightens susceptibility to OVA - induced allergic intestinal inflammation. EL - Antibiotics cause intestinal dysbiosis, like Clostridia and Muribaculaceae depletion and Sutterellaceae enrichment, disrupting tryptophan metabolism and reducing nicotinic acid (NA). NA deficiency impairs gut barrier and Th2/Treg balance. However, NA supplementation restores these via GPR109A. In human pediatric cohorts, food - allergic children with EL - Antibiotic exposure have lower gut NA levels. We integrated mouse and human data with multi - omics, revealing EL - Abx regulates FA through the "microbiota - metabolism - immunity" axis, and suggest targeting NA pathway to counter Antibiotic - related FA risk.

Keywords

Early life antibiotic exposure; Food allergy; Gut microbiome; Nicotinic acid; Prospective pediatric cohorts; Tryptophan metabolism.

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