2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Antibiotic Aminoacyl-tRNA Synthetase
  4. Mupirocin lithium

Mupirocin lithium  (Synonyms: BRL-4910A lithium; Pseudomonic acid lithium)

Cat. No.: HY-W108875 Purity: ≥97.0%
COA
SDS
Handling Instructions Technical Support

Mupirocin lithium is an antibiotic. Mupirocin lithium inhibits bacterial isoleucyl-tRNA synthetase, blocking protein synthesis. Mupirocin lithium has high activity against Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as some Gram-negative bacteria (such as Haemophilus influenzae). Mupirocin lithium can be used in the research of diseases such as skin infections (such as MRSA infections) and chronic sinusitis.

For research use only. We do not sell to patients.

Mupirocin lithium Chemical Structure

Mupirocin lithium Chemical Structure

CAS No. : 73346-79-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Mupirocin lithium:

Mupirocin lithium Related Antibodies

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Description

Mupirocin lithium is an antibiotic. Mupirocin lithium inhibits bacterial isoleucyl-tRNA synthetase, blocking protein synthesis. Mupirocin lithium has high activity against Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as some Gram-negative bacteria (such as Haemophilus influenzae). Mupirocin lithium can be used in the research of diseases such as skin infections (such as MRSA infections) and chronic sinusitis[1][2][3][4][5][6].

In Vitro

Mupirocin lithium inhibits staphylococci and streptococci (except group D streptococci), with a MIC of ≤0.5 μg/mL[1].
Mupirocin (0.1-0.2 mM; 18 h) lithium significantly increases wound closure and proliferation of human keratinocytes (HaCat) and enhances production of growth factors like HGF and PDGF-AA[4].
Mupirocin (≤125 μg/mL) lithium reduces biofilm mass by greater than 90% in all S. aureus isolates[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mupirocin lithium Related Antibodies
In Vivo

Mupirocin (2%; topical application; twice daily; 3-6 days) lithium reduces bacterial loads in murine superficial skin wounds infected with MRSA USA300[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (10-12 weeks old) with superficial skin wound infection induced by MRSA USA300[3]
Dosage: 2%
Administration: Topical application to the lesion area, twice daily, for 3 days or 6 days
Result: Reduced bacterial loads in the skin lesions by 2.0 log CFU after 3 days of treatment.
Reduced bacterial loads in the skin lesions by 5.1 log CFU after 6 days of treatment.
Clinical Trial
Molecular Weight

506.56

Formula

C26H43LiO9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@](CO[C@@H](C/C(C)=C/C(OCCCCCCCCC(O[Li])=O)=O)[C@@H]1O)([H])C[C@H]2[C@@]([C@@H](C)[C@@H](O)C)([H])O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (197.41 mM; Need ultrasonic)

DMSO : 50 mg/mL (98.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9741 mL 9.8705 mL 19.7410 mL
5 mM 0.3948 mL 1.9741 mL 3.9482 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (243 KB) HNMR (140 KB) MS (73 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9741 mL 9.8705 mL 19.7410 mL 49.3525 mL
5 mM 0.3948 mL 1.9741 mL 3.9482 mL 9.8705 mL
10 mM 0.1974 mL 0.9870 mL 1.9741 mL 4.9352 mL
15 mM 0.1316 mL 0.6580 mL 1.3161 mL 3.2902 mL
20 mM 0.0987 mL 0.4935 mL 0.9870 mL 2.4676 mL
25 mM 0.0790 mL 0.3948 mL 0.7896 mL 1.9741 mL
30 mM 0.0658 mL 0.3290 mL 0.6580 mL 1.6451 mL
40 mM 0.0494 mL 0.2468 mL 0.4935 mL 1.2338 mL
50 mM 0.0395 mL 0.1974 mL 0.3948 mL 0.9870 mL
60 mM 0.0329 mL 0.1645 mL 0.3290 mL 0.8225 mL
80 mM 0.0247 mL 0.1234 mL 0.2468 mL 0.6169 mL
H2O 100 mM 0.0197 mL 0.0987 mL 0.1974 mL 0.4935 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mupirocin lithium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mupirocin73346-79-9BRL-4910APseudomonic acidBacterialAntibioticAminoacyl-tRNA SynthetasetRNA Synthetase, aaRSMeticillin-resistant Staphylococcus aureusMRSAointmentpolyethylene glycol basereversibly inhibitionisoleucyl-transfer RNARNA synthesisInhibitorinhibitorinhibit

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