2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. Ligands for Target Protein for PROTAC Aurora Kinase
  4. Aurora-A ligand 1

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma.

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Aurora-A ligand 1 Chemical Structure

Aurora-A ligand 1 Chemical Structure

CAS No. : 2541626-73-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Aurora-A ligand 1 Related Antibodies

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Description

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1].

Molecular Weight

393.44

Formula

C21H23N5O3
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(O)=O)C=C4)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5417 mL 12.7084 mL 25.4168 mL
5 mM 0.5083 mL 2.5417 mL 5.0834 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5417 mL 12.7084 mL 25.4168 mL 63.5421 mL
5 mM 0.5083 mL 2.5417 mL 5.0834 mL 12.7084 mL
10 mM 0.2542 mL 1.2708 mL 2.5417 mL 6.3542 mL
15 mM 0.1694 mL 0.8472 mL 1.6945 mL 4.2361 mL
20 mM 0.1271 mL 0.6354 mL 1.2708 mL 3.1771 mL
25 mM 0.1017 mL 0.5083 mL 1.0167 mL 2.5417 mL
30 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1181 mL
40 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.5886 mL
50 mM 0.0508 mL 0.2542 mL 0.5083 mL 1.2708 mL
60 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0590 mL
80 mM 0.0318 mL 0.1589 mL 0.3177 mL 0.7943 mL
100 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.6354 mL
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Aurora-A ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora-A ligand 12541626-73-5Ligands for Target Protein for PROTACAurora KinaseTarget Protein-binding MoietyAntitumorNeuroblastomaXenograftSK-N-BENB cellMR-32 cell.Inhibitorinhibitorinhibit

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