Cefetamet hydrochloride  (Synonyms: Ro 15-8074 hydrochloride; Deacetoxycefotaxime hydrochloride)

Cefetamet (Ro 15-8074) hydrochloride is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet hydrochloride binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet hydrochloride has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet hydrochloride kills and lyses Treponema pallidum. Cefetamet hydrochloride can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis^{[1][2][3][4][5]}.

IC₅₀: 2.5 μg/mL (PBP3 in Escherichia coli W3110^[3]

Cefetamet hydrochloride exhibits high in vitro activity against most members of the Enterobacteriaceae, Haemophilus influenzae, Neisseria spp., and Streptococcus pneumoniae (MIC₉₀ ≤ 2 μg/mL)^[2].
Cefetamet hydrochloride shows high in vitro activity against Enterobacteriaceae, Neisseria spp., Vibrio spp., Haemophilus influenzae and streptococci other than enterococci^[3].
Cefetamet hydrochloride exhibits poor affinity for the PBPs of Staphylococcus aureus, with IC₅₀s of 90, >100, 52 and >100 μg/mL for PBP 1 to 4^[3].
Cefetamet (0.05-0.1 μg/mL; 24 h) hydrochloride kills and lyses Treponema pallidum in vitro^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefetamet (1-30 mg/kg; i.m.; once) hydrochloride cures experimental syphilis in rabbits, with the best effect when administered before clinical manifestations^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

433.89

C₁₄H₁₆ClN₅O₅S₂

724438-16-8

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang W, et al. Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog. Eur J Drug Metab Pharmacokinet. 2015 Dec;40(4):401-7.  [Content Brief]

  [2]. Wise R, et al. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother. 1986 Jun;29(6):1067-72.  [Content Brief]

  [3]. Angehrn P, et al. In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil. Eur J Clin Microbiol Infect Dis. 1989 Jun;8(6):536-43.  [Content Brief]

  [4]. Fitzgerald TJ. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis. Antimicrob Agents Chemother. 1992 Mar;36(3):598-602.  [Content Brief]

  [5]. Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993;45(4):589-621.  [Content Brief]