2. Anti-infection Autophagy Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein
  4. Bifendate (Standard)

Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR).

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Bifendate (Standard)

Bifendate (Standard) Chemical Structure

CAS No. : 73536-69-3

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SMILES

C2=C(OC)C1=C(OCO1)C(=C2C(OC)=O)C3=C(C=C(OC)C4=C3OCO4)C(OC)=O
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Bifendate (Standard) Related Classifications

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Keywords:

Bifendate (Standard)73536-69-3HBVAutophagyCytochrome P450Atg8/LC3p62P-glycoproteinHepatitis B virusCYPsAutophagy-related 8Sequestosome-1SQSTM1P-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Schisandrin Cchronic hepatitis Banti-HBVautophagylipid accumulationanti-oxidantALTMDRInhibitorinhibitorinhibit

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