2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) Ferroptosis
  4. Ferumoxytol

Ferumoxytol is an iron oxide nanoparticle. Ferumoxytol has anti-leukemic activity, especially against acute myeloid leukemia (AML) cells with low iron transporter protein (FPN) expression. Ferumoxytol increases intracellular iron content, triggers the Fenton reaction, generates reactive oxygen species (ROS), leads to oxidative stress and ferroptosis. Ferumoxytol can selectively kill leukemic cells with low FPN expression while avoiding toxicity to normal cells. Ferumoxytol can be used to study leukemias with targeted iron metabolism abnormalities.

For research use only. We do not sell to patients.

Ferumoxytol Chemical Structure

Ferumoxytol Chemical Structure

CAS No. : 722492-56-0

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Description

Ferumoxytol is an iron oxide nanoparticle. Ferumoxytol has anti-leukemic activity, especially against acute myeloid leukemia (AML) cells with low iron transporter protein (FPN) expression. Ferumoxytol increases intracellular iron content, triggers the Fenton reaction, generates reactive oxygen species (ROS), leads to oxidative stress and ferroptosis. Ferumoxytol can selectively kill leukemic cells with low FPN expression while avoiding toxicity to normal cells. Ferumoxytol can be used to study leukemias with targeted iron metabolism abnormalities[1].

Clinical Trial
CAS No.
Appearance

Liquid

Color

Light brown to brown

SMILES

[Ferumoxytol]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Handling Instructions (2659 KB)
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Ferumoxytol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferumoxytol722492-56-0Reactive Oxygen Species (ROS)FerroptosisNanoparticlesFPNAMLFentonROSInhibitorinhibitorinhibit

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