2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. PVTX-321

PVTX-321 (Compound 16a) is an orally active estrogen receptor α (ERα) degrader. PVTX-321 can potently degrade ERα (DC50=0.15 nM in MCF-7 cells) and also has inhibitory activity against mutant ERα (IC50=59 nM). PVTX-321 is promising for research of ER+/HER2- breast cancer.

For research use only. We do not sell to patients.

PVTX-321 Chemical Structure

PVTX-321 Chemical Structure

CAS No. : 3026004-38-3

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PVTX-321 Related Antibodies

Top Publications Citing Use of Products

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

PVTX-321 (Compound 16a) is an orally active estrogen receptor α (ERα) degrader. PVTX-321 can potently degrade ERα (DC50=0.15 nM in MCF-7 cells) and also has inhibitory activity against mutant ERα (IC50=59 nM). PVTX-321 is promising for research of ER+/HER2- breast cancer[1].

IC50 & Target

ERα

 

Molecular Weight

839.00

Formula

C51H55FN4O6
CAS No.
SMILES

OC1=CC2=C(C=C1)[C@@H](C3=CC(F)=C(N4CCC5(CC4)CC(CN6CCC7(CC6)C8=CC=C9C(CN([C@H]%10CCC(NC%10=O)=O)C9=O)=C8OC7)C5)C=C3OC)[C@@H](C%11=CC=CC=C%11)CC2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PVTX-321 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PVTX-3213026004-38-3PVTX321PVTX 321Estrogen Receptor/ERRERαbreast cancerInhibitorinhibitorinhibit

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