2. Metabolic Enzyme/Protease Anti-infection Others
  3. Fungal Tyrosinase Bacterial Drug Derivative
  4. 4-Chlorocinnamic acid

4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A). 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol.

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4-Chlorocinnamic acid

4-Chlorocinnamic acid Chemical Structure

CAS No. : 1615-02-7

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Based on 1 publication(s) in Google Scholar

4-Chlorocinnamic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 4-Chlorocinnamic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A). 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4].

IC50 & Target

IC50 values: 0.477 mM and 0.229 mM for monophenolase and diphenolase activities of mushroom tyrosinase, respectively
In Vitro

4-Chlorocinnamic acid inhibits both monophenolase and diphenolase activities of mushroom tyrosinase, with IC50 values of 0.477 mM and 0.229 mM, respectively[1].
4-Chlorocinnamic acid (0.5 mg/mL) inhibits the mycelial growth of Colletotrichum gloeosporioides in vitro with an inhibition rate of approximately 65%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Chlorocinnamic acid Related Antibodies

Cell Viability Assay[3]

Cell Line: MRC-5 fibroblasts
Concentration: 3.12 μg/mL, 6.25 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL
Incubation Time: 72 h
Result: Did not significantly reduce the viability of MRC-5 fibroblasts at concentrations lower than 100 μg/mL.
Showed an IC50 value of >100 μg/mL.
In Vivo

4-Chlorocinnamic acid (100-300 mg/kg; i.p.) exhibits anticonvulsant activity in Kunming mice with acute seizure induced by Pentylenetetrazol[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (both genders, weight 25-30 g) with PTZ-induced acute seizures[4]
Dosage: 100 mg/kg, 200 mg/kg, 300 mg/kg
Administration: intraperitoneal injection
Result: Prolonged the latent time of PTZ-induced seizures to 214.0 s, reduced the tonic seizure rate to 25% and the mortality rate to 50% (at the dose of 300 mg/kg).
Molecular Weight

182.61

Formula

C9H7ClO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C/C1=CC=C(Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (547.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4762 mL 27.3808 mL 54.7615 mL
5 mM 1.0952 mL 5.4762 mL 10.9523 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (27.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.98%

SDS (393 KB)

COA (244 KB) HNMR (95 KB) RP-HPLC (177 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4762 mL 27.3808 mL 54.7615 mL 136.9038 mL
5 mM 1.0952 mL 5.4762 mL 10.9523 mL 27.3808 mL
10 mM 0.5476 mL 2.7381 mL 5.4762 mL 13.6904 mL
15 mM 0.3651 mL 1.8254 mL 3.6508 mL 9.1269 mL
20 mM 0.2738 mL 1.3690 mL 2.7381 mL 6.8452 mL
25 mM 0.2190 mL 1.0952 mL 2.1905 mL 5.4762 mL
30 mM 0.1825 mL 0.9127 mL 1.8254 mL 4.5635 mL
40 mM 0.1369 mL 0.6845 mL 1.3690 mL 3.4226 mL
50 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7381 mL
60 mM 0.0913 mL 0.4563 mL 0.9127 mL 2.2817 mL
80 mM 0.0685 mL 0.3423 mL 0.6845 mL 1.7113 mL
100 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3690 mL
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4-Chlorocinnamic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Chlorocinnamic acid1615-02-7FungalTyrosinaseBacterialDrug DerivativeDrug derivativeInfectionanthracnoseantibacterialInhibitorinhibitorinhibit

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