Oxamic acid sodium (Synonyms: Sodium oxamate)

Name: Oxamic acid sodium
Brand: MedChemExpress
SKU: HY-W013032A
Rating: 5.0 (19 reviews)

Cat. No.: HY-W013032A Purity: 99.72%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.

For research use only. We do not sell to patients.

Oxamic acid sodium Chemical Structure

CAS No. : 565-73-1

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Based on 19 publication(s) in Google Scholar

Other Forms of Oxamic acid sodium:

Oxamic acid Get quote

14 Publications Citing Use of MCE Oxamic acid sodium

RT-PCR

: Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jan 21:488:137310. [Abstract]; After treating BV-2 cells with 0 or 10 µM oxamate (OX) for 2 h, cells were treated with 0 % or 6 % CSE for 24 h. Representative immunoblot images of NLRP3.

: Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]; Oxamic acid (Ox) (20 mM; 24 h) treatment in AGEs-induced mTEC dramatically downregulated the levels of Pan kla and H3K14la.

: Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]; Oxamic acid (Ox) (20 mM; 24 h) markedly inhibits the expression of fibrogenic genes (snail1, snail2, and twist1) in AGEs-stimulated mTEC, but no significant effect on quiescent cells.

: Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246. [Abstract]; Oxamic acid (Ox) (0.75 g/kg; i.p.; once daily for 4 weeks). Immunofluorescent staining of E-cadherin (red), ɑ-SMA (green), and DAPI (blue).

: Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 Jul 3;13(11):3856-3871. [Abstract]; Oxamic acid (10 mM) reverses the increase of Klac-HMGB1 levels in H/R-Ko hepatocytes.

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	45.8 mM Compound: Oxamate sodium	Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay	[PMID: 31129449]
MIA PaCa-2	IC₅₀	18.9 mM Compound: Oxamate sodium	Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31129449]

In Vitro

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells^[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells^[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells^[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells^[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	CNE-1 and CNE-2 cells
Concentration:	10 μM
Incubation Time:	24-72 hours
Result:	Showed IC₅₀s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.

Apoptosis Analysis^[2]

Cell Line:	NPC cells
Concentration:	0, 20, 50 and 100 mM
Incubation Time:	48 hours
Result:	Showed the increasement of early and late apoptotic cells in a dose-dependent manner. Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.

Cell Cycle Analysis^[2]

Cell Line:	CNE-1 and CNE-2 cells
Concentration:	0, 20, 50 and 100 mM
Incubation Time:	24 hours
Result:	Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.

In Vivo

Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Balb/c nude mice injected with CNE-1 cells^[2]
Dosage:	750 mg/kg
Administration:	Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
Result:	Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.

Molecular Weight

111.03

Formula

C₂H₂NNaO₃

CAS No.

565-73-1

Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)C(=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 12.5 mg/mL (112.58 mM; Need ultrasonic)

DMSO : 3.23 mg/mL (29.09 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.0066 mL	45.0329 mL	90.0658 mL
5 mM	1.8013 mL	9.0066 mL	18.0132 mL
10 mM	0.9007 mL	4.5033 mL	9.0066 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline
Solubility: 75 mg/mL (675.49 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (246 KB) LCMS (84 KB)

Handling Instructions (2659 KB)

References

[1]. Xiang J, et al. LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells. Aging (Albany NY). 2021 Dec 16;13(24):25920-25930. [Content Brief]

[2]. Zhai X, et al. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 2013 Dec;30(6):2983-91. [Content Brief]

[3]. Muramatsu H, et al. Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells. Oncol Rep. 2019 Jul;42(1):224-230. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	9.0066 mL	45.0329 mL	90.0657 mL	225.1644 mL
	5 mM	1.8013 mL	9.0066 mL	18.0131 mL	45.0329 mL
	10 mM	0.9007 mL	4.5033 mL	9.0066 mL	22.5164 mL
	15 mM	0.6004 mL	3.0022 mL	6.0044 mL	15.0110 mL
	20 mM	0.4503 mL	2.2516 mL	4.5033 mL	11.2582 mL
	25 mM	0.3603 mL	1.8013 mL	3.6026 mL	9.0066 mL
H₂O	30 mM	0.3002 mL	1.5011 mL	3.0022 mL	7.5055 mL
	40 mM	0.2252 mL	1.1258 mL	2.2516 mL	5.6291 mL
	50 mM	0.1801 mL	0.9007 mL	1.8013 mL	4.5033 mL
	60 mM	0.1501 mL	0.7505 mL	1.5011 mL	3.7527 mL
	80 mM	0.1126 mL	0.5629 mL	1.1258 mL	2.8146 mL
	100 mM	0.0901 mL	0.4503 mL	0.9007 mL	2.2516 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Oxamic acid sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxamic acid565-73-1Sodium oxamateLactate DehydrogenaseApoptosisLDHanti-tumor activityanti-proliferative activityinduce apoptosisCNE-1CNE-2A2780SKOV3Inhibitorinhibitorinhibit

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Oxamic acid sodium (Synonyms: Sodium oxamate)

Customer Review

Other Forms of Oxamic acid sodium:

Oxamic acid sodium Related Antibodies

14 Publications Citing Use of MCE Oxamic acid sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Oxamic acid sodium Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Oxamic acid sodium Related Classifications

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