2. Metabolic Enzyme/Protease Anti-infection
  3. Herbicide Bacterial
  4. Diclosulam

Diclosulam (XDE 564) is a herbicide with a Ki value of ＜32 nM and MIC and MIC50 values of 6.25, 1.40, 12.5 and 3.01 μM against CBS10913 and CBS12373 strains, respectively.

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Diclosulam Chemical Structure

Diclosulam Chemical Structure

CAS No. : 145701-21-9

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Diclosulam Related Antibodies

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Description

Diclosulam (XDE 564) is a herbicide with a Ki value of ＜32 nM and MIC and MIC50 values of 6.25, 1.40, 12.5 and 3.01 μM against CBS10913 and CBS12373 strains, respectively[1].

Molecular Weight

406.22

Formula

C13H10Cl2FN5O3S
CAS No.
Appearance

Solid

SMILES

O=S(C1=NN2C(OCC)=NC(F)=CC2=N1)(NC3=C(Cl)C=CC=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (246.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4617 mL 12.3086 mL 24.6172 mL
5 mM 0.4923 mL 2.4617 mL 4.9234 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.20%

COA (252 KB) HNMR (161 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4617 mL 12.3086 mL 24.6172 mL 61.5430 mL
5 mM 0.4923 mL 2.4617 mL 4.9234 mL 12.3086 mL
10 mM 0.2462 mL 1.2309 mL 2.4617 mL 6.1543 mL
15 mM 0.1641 mL 0.8206 mL 1.6411 mL 4.1029 mL
20 mM 0.1231 mL 0.6154 mL 1.2309 mL 3.0772 mL
25 mM 0.0985 mL 0.4923 mL 0.9847 mL 2.4617 mL
30 mM 0.0821 mL 0.4103 mL 0.8206 mL 2.0514 mL
40 mM 0.0615 mL 0.3077 mL 0.6154 mL 1.5386 mL
50 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2309 mL
60 mM 0.0410 mL 0.2051 mL 0.4103 mL 1.0257 mL
80 mM 0.0308 mL 0.1539 mL 0.3077 mL 0.7693 mL
100 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL
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Diclosulam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diclosulam145701-21-9XDE 564XDE564XDE-564HerbicideBacterialCBS10913CBS12373Inhibitorinhibitorinhibit

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